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NeuroImages: IgG4-related disease with meningeal and parenchymal involvement on MRI and histopathology

Lina Li1, Haibing Xiao2,3

  • 1Department of Neuromedicine Center, The University of Hong Kong-Shenzhen Hospital, Shenzhen, Guangdong, China.

Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology
|July 10, 2025
PubMed

Insights

Immunoglobulin G4-related disease (IgG4-RD) is a rare condition affecting the central nervous system. This case highlights the importance of considering IgG4-RD in meningo-parenchymal lesions for prompt diagnosis and treatment.

Area of Science:

  • Neurology
  • Immunology
  • Pathology

Background:

  • Immunoglobulin G4-related disease (IgG4-RD) is a multisystem fibroinflammatory condition.
  • Central Nervous System (CNS) parenchymal involvement in IgG4-RD is exceptionally rare.
Keywords:
Central nervous systemGlucocorticoidsIgG4-related diseaseParenchymal involvement

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