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Cellular senescence and disulfide death-related genes as biological markers of breast cancer prognosis

  • 0Department of Breast and Thyroid Surgery, Hainan Women and Children's Medical Center, Haikou, Hainan, People's Republic of China.
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July 10, 2025

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July 10, 2025

View abstract on PubMed

Summary

This summary is machine-generated.

This study identified genes linked to cellular senescence and disulfide death in breast cancer. A predictive model using ACTN2 and CHD4 genes shows promise for forecasting patient prognosis.

Area Of Science

  • Oncology
  • Molecular Biology
  • Genetics

Background

  • Breast cancer is a complex disease with varied outcomes.
  • Understanding molecular drivers of prognosis is crucial for personalized treatment.

Purpose Of The Study

  • To identify genes associated with cellular senescence and disulfide death in breast cancer.
  • To develop a predictive model for breast cancer prognosis using these genes.
  • To explore potential clinical applications of these genetic markers.

Main Methods

  • Screened differential genes related to cellular senescence and disulfide death.
  • Constructed a protein-protein interaction network and performed functional enrichment analysis (GO, KEGG).
  • Developed a prognostic risk model using TCGA-BRCA data and LASSO regression, validated with Cox regression and GSEA/GSVA.

Main Results

  • Identified 17 differential genes. A LASSO regression model identified ACTN2 and CHD4 as key prognostic genes.
  • The LASSO risk score and pathological stage significantly improved prognostic prediction.
  • The multifactor Cox regression model demonstrated predictive utility for 1, 3, and 5-year survival.

Conclusions

  • Genes involved in cellular senescence and disulfide death can be used to build predictive models for breast cancer prognosis.
  • These findings offer potential for improved clinical decision-making and patient stratification.

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