Somatostatin receptor expression in multiple hemangiomas
Benjin Liu1, Shangjian Li1, Yisi Xu1
1Department of Urology, Shandong Provincial Hospital Affiliated with Shandong First Medical University, Jinan, China.
Discover Oncology
|July 10, 2025
Summary
This study reports a rare case of hemangioma expressing somatostatin receptors (SSTRs) in a 66-year-old female. This finding offers insights into atypical hemangioma presentations and potential therapeutic strategies for these vascular tumors.
Area of Science:
- Vascular Tumors
- Oncology
- Molecular Imaging
Background:
- Hemangiomas are common vascular tumors but rarely occur in the retroperitoneum.
- Expression of somatostatin receptors (SSTRs) in hemangiomas is exceptionally uncommon.
- This case represents the second documented instance of multiple hemangiomas exhibiting SSTR expression.
Purpose of the Study:
- To report a rare case of hemangioma with somatostatin receptor expression.
- To discuss the diagnostic and therapeutic implications of this atypical finding.
Main Methods:
- A 66-year-old female presented with multiple hypervascular lesions.
- Imaging (CT, PET) suggested metastatic paraganglioma.
- Surgical resection and histopathological analysis confirmed hemangioma with SSTR2 expression.
Main Results:
- Histopathology confirmed hemangioma with positive endothelial markers (CD31, CD34).
- Immunohistochemistry revealed expression of somatostatin receptor 2 (SSTR2).
- The patient's lesions were initially misdiagnosed due to their unusual location and presentation.
Conclusions:
- This case underscores the rare but possible expression of SSTRs in hemangiomas.
- Recognizing such atypical presentations is crucial for accurate diagnosis and management.
- SSTR expression in hemangiomas may offer novel therapeutic targets.
