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Related Experiment Video

Updated: Sep 16, 2025

A Comprehensive Procedure to Evaluate the In Vitro Performance of the Putative Hemangioblastoma Neovascularization Using the Spheroid Sprouting Assay

A Comprehensive Procedure to Evaluate the In Vitro Performance of the Putative Hemangioblastoma Neovascularization Using the Spheroid Sprouting Assay

Published on: April 12, 2018

Somatostatin receptor expression in multiple hemangiomas.

Benjin Liu¹, Shangjian Li¹, Yisi Xu¹

¹Department of Urology, Shandong Provincial Hospital Affiliated with Shandong First Medical University, Jinan, China.

Discover Oncology

|July 10, 2025

Summary

This study reports a rare case of hemangioma expressing somatostatin receptors (SSTRs) in a 66-year-old female. This finding offers insights into atypical hemangioma presentations and potential therapeutic strategies for these vascular tumors.

Keywords:

68Ga-DOTATATE PET/CT Hemangioma Neuroendocrine tumor Retroperitoneum Somatostatin receptor

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Last Updated: Sep 16, 2025

A Comprehensive Procedure to Evaluate the In Vitro Performance of the Putative Hemangioblastoma Neovascularization Using the Spheroid Sprouting Assay

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Published on: April 12, 2018

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Published on: August 7, 2016

Quantitation of Protein Expression and Co-localization Using Multiplexed Immuno-histochemical Staining and Multispectral Imaging

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Published on: April 8, 2016

Area of Science:

Vascular Tumors
Oncology
Molecular Imaging

Background:

Hemangiomas are common vascular tumors but rarely occur in the retroperitoneum.
Expression of somatostatin receptors (SSTRs) in hemangiomas is exceptionally uncommon.
This case represents the second documented instance of multiple hemangiomas exhibiting SSTR expression.

Purpose of the Study:

To report a rare case of hemangioma with somatostatin receptor expression.
To discuss the diagnostic and therapeutic implications of this atypical finding.

Main Methods:

A 66-year-old female presented with multiple hypervascular lesions.
Imaging (CT, PET) suggested metastatic paraganglioma.
Surgical resection and histopathological analysis confirmed hemangioma with SSTR2 expression.

Main Results:

Histopathology confirmed hemangioma with positive endothelial markers (CD31, CD34).
Immunohistochemistry revealed expression of somatostatin receptor 2 (SSTR2).
The patient's lesions were initially misdiagnosed due to their unusual location and presentation.

Conclusions:

This case underscores the rare but possible expression of SSTRs in hemangiomas.
Recognizing such atypical presentations is crucial for accurate diagnosis and management.
SSTR expression in hemangiomas may offer novel therapeutic targets.