Related Experiment Video
Updated: Sep 16, 2025
A Novel Digital Platform for a Monitored Home-based Cardiac Rehabilitation Program
Published on: April 19, 2019
The Dose-Response Relationship of Aerobic Exercise on Cardiorespiratory Fitness in Cardiac Rehabilitation: A
Blake E G Collins1, Brett A Gordon, Daniel W T Wundersitz
1Author Affiliations: Holsworth Research Initiative, La Trobe Rural Health School, La Trobe University, Bendigo, Victoria, Australia (Dr Collins, Dr Gordon, Dr Wundersitz, and Mr Kingsley); Sport, Performance, and Nutrition Research Group, School of Allied Health, Human Services and Sport, La Trobe University, Bendigo, Victoria, Australia (Dr Carey); and Department of Exercise Sciences, Faculty of Science, University of Auckland, Auckland, New Zealand (Mr Kingsley).
Objective:
To explore the incremental dose-response effect of aerobic exercise-based cardiac rehabilitation programs (ExCRP) on cardiorespiratory fitness in comparison to non-exercise controls among people with coronary heart disease (CHD).
Review Methods:
Medline, CINAHL, Cochrane, SCOPUS, and SPORTDiscus were searched from January 1, 2000 until December 4, 2023. Articles were eligible for selection if they satisfied the following criteria: randomized controlled studies assessing change in cardiorespiratory fitness among people with CHD in non-exercise and aerobic intervention groups, established peak oxygen uptake via cardiopulmonary exercise test, minimum of 4-week program duration, and reported frequency, intensity, and duration of prescribed exercise. The study was prospectively registered (PROSPERO ID: CRD42021274924).
Summary:
Thirty-three studies, including 1901 participants were included in the continuous dose-analysis. A significant difference in cardiorespiratory fitness was identified between ExCRP and non-exercise control that favored exercise by 3.4 (3.0-3.9) mL·kg -1 ·min -1 . No difference existed between interval and continuous training when matched for exercise dose. Dose-response analyses identified a significant increase in cardiorespiratory fitness (3.4 [2.9-5.5] mL·kg -1 ·min -1 ) associated with program completion, with no additional benefit related to increased exercise dose. When compared to non-exercise control, participating in ExCRP with a minimum total program intervention dose of 2194 metabolic equivalent minutes significantly improves cardiorespiratory fitness. However, no additional benefit was discernible from higher exercise doses. Although the recommended dose for ExCRP augments medical treatment and is sufficient to improve cardiorespiratory fitness, it is likely that the narrow range in prescribed exercise dose and variations in the fidelity of exercise interventions limit interpretation.
More Related Videos
07:10Home-Based Prescribed Pulmonary Exercise in Patients with Stable Chronic Obstructive Pulmonary Disease
Published on: August 24, 2019
07:26Conducting Maximal and Submaximal Endurance Exercise Testing to Measure Physiological and Biological Responses to Acute Exercise in Humans
Published on: October 17, 2018
Related Concept Videos
01:17Exercise and Cardiac Output
Sustained exercise increases the muscles' oxygen demand, which can be...
01:20Exercise and Cardiovascular Response
Light to moderate physical activity initiates a series of interconnected responses in the body. The heart rate modestly increases in anticipation of the workout, followed by widespread vasodilation as oxygen consumption by skeletal muscles increases. This results in decreased peripheral resistance, increased capillary blood flow, and accelerated...
01:03Dose-Response Relationship: Overview
01:19Cardiac Output I:Effect of Heart Rate on Cardiac Output
Cardiac output (CO) refers to the total amount of blood ejected by one of the ventricles in liters per minute (L/min). In a resting adult, CO ranges from 5 to 6 L/min, adjusting according to the body's metabolic requirements.
Effect of Heart Rate on Cardiac Output
Cardiac output adapts to metabolic demands during stress, physical activity, or illness. The autonomic nervous system regulates heart rate via the sinoatrial node. The parasympathetic nervous system decreases heart...
01:22Dose-Response Relationship: Potency and Efficacy
01:27Exercise and Muscle Performance
Endurance exercises
Endurance exercises involve running, swimming, or cycling, which require repetitive movements with low force output. When a person engages in endurance exercise, a few noticeable changes occur in their skeletal muscles. For instance, the number of capillaries...