Related Experiment Video
Updated: Sep 16, 2025
Treatment with Locking Intramedullary Nailing for Intertrochanteric Fracture of the Femur Utilizing a New Awl with a Distal Positioner
Published on: June 6, 2025
Calcitonin Gene-Related Peptide Antagonist Use and Atypical Femur Fractures: A Case Report
Kenneth Choy1,2, Jason J McDonald1,2, Matthew Geiselmann1,2
1Department of Orthopaedic Surgery, Northwell Health Huntington Hospital, Huntington, New York.
Case:
A 56-year-old woman presented with bilateral hip pain status postmechanical fall. Imaging confirmed bilateral AFFs with lateral cortical beaking. The patient was found to be on a calcitonin gene-related peptide (CGRP) antagonist, Erenumab, for treatment of recurrent migraines. CGRP is a neuropeptide and vasodilator produced by neurons in both the central and peripheral nervous system. She was treated with bilateral femoral intramedullary nails, followed by postoperative rehabilitation with physical therapy and outpatient follow-up visits.
Conclusion:
Erenumab is a CGRP antagonist, which increases bone formation, and may be associated with atypical femur fractures. Further investigations are warranted.
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