Diversity Oriented Synthesis, Insecticidal Evaluation, and Molecular Docking of Some Insect Growth Regulators Analogs...

One of the main forces for the creation of new insecticidal substances is the growing resistance to traditional chemical pesticides. Researchers are looking at novel pesticide categories with safe and distinctive modes of action to address this dilemma. In this study, lufenuron and nine other synthesized IGRs were tested against Hypera brunneipennis, and bioassay data was recorded to evaluate these chemical compounds as insecticidal agents suitable for IPM protocol. The results of bioassay tests indicate that lufenuron has an LC₅₀ value equal to 37.25 ppm against the fourth instar of the H. brunneipennis insect; however, compound 8 has the best insecticidal activity, with an LC₅₀ value equal to 32.65 ppm, and other synthesized compounds have medium to high toxicological activity. On the other hand, using IGRs against H. brunneipennis is more preferred than other traditional chemical insecticides. This fact is crucial when controlling alfalfa pests because of their minimal toxic impact against nontarget organisms and low toxic residual effect. A variety of binding affinities and interaction profiles are shown by molecular docking studies, with residues like TYR121, SER122, and TYR130 playing a major role in important interactions. The chemicals under investigation exhibit significant bindings to the target protein by forming vast hydrogen bond networks with numerous amino acids.