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Molybdenum exposure causes kidney damage related to the excretion of heavy metals

Hong Ren1, Xiaoyun Shen2

  • 1College of Life Science and Agri-forestry, Southwest University of Science and Technology, Mianyang 621010, China; North Sichuan Medical College, Nanchong 637100, China.

Ecotoxicology and Environmental Safety
|July 10, 2025
PubMed

Insights

Molybdenum (Mo) exposure damages kidneys by disrupting metabolic pathways. Key pathways like arachidonic acid metabolism and steroid hormone biosynthesis are implicated in this heavy metal excretion injury.

Area of Science:

  • Environmental Toxicology
  • Renal Physiology
  • Metabolomics

Background:

  • Renal excretion is a critical route for heavy metal metabolism.
  • Molybdenum (Mo) exposure can induce significant kidney damage.

Purpose of the Study:

  • To establish an animal model of molybdenum toxicity.
  • To elucidate the molecular mechanisms of kidney injury induced by Mo exposure.

Main Methods:

  • Animal modeling of molybdenum toxicity.
  • Multi-omics analyses to identify regulatory networks.
  • Biomarker identification.

Main Results:

  • Molybdenum exposure caused structural and functional kidney damage.
  • A regulatory network involving "Arachidonic acid metabolism," "Steroid hormone biosynthesis," "Folate biosynthesis," and "Retrograde endocannabinoid signaling" was identified.
  • Epoxide hydrolase 2 was upregulated and identified as a potential key biomarker.

Conclusions:

  • The identified regulatory network is crucial in molybdenum-induced renal heavy metal excretion injury.
  • This study offers insights into heavy metal excretion mechanisms and kidney damage.
  • Findings provide directions for preventing and treating heavy metal-induced kidney damage.
Keywords:
ExcretionHeavy metalsKidneysMolybdenum exposureRegulation

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