Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Methods of reducing fever01:22

Methods of reducing fever

773
The signs and symptoms of fever include hot and dry skin, flushed face, thirst, muscle aches, anorexia, headache, tachycardia, tachypnea, and fatigue. Elevated body temperature is reduced using two methods: pharmacological and nonpharmacological. Proper identification and treatment of the root cause of a fever is of utmost importance.
Pharmacological Methods of Reducing Fever:
773
Rheumatic Heart Disease III: Medical Management01:21

Rheumatic Heart Disease III: Medical Management

36
Rheumatic heart disease (RHD) management can be divided into two main strategies: prevention and long-term management.Primary PreventionPrimary prevention focuses on timely diagnosis and management of group A streptococcal pharyngitis to prevent acute rheumatic fever. The most widely used antibiotic for treating this condition is intramuscular benzathine penicillin G.Acute Rheumatic Fever TreatmentThe primary treatment goal for a patient diagnosed with acute rheumatic fever is to suppress the...
36
Increased Body Temperature01:25

Increased Body Temperature

2.3K
A body temperature above  38°C  (100.4 °F) is known as fever or pyrexia, and a person with fever is termed 'febrile.' Typically, the hypothalamus, a part of the brain that acts as the body's thermostat, regulates body temperature through a thermoregulatory setpoint. It receives signals from cold and warm thermal receptors throughout the body and adjusts the body's temperature accordingly. Fever occurs when this hypothalamic setpoint is altered, usually in...
2.3K
Venous Thrombosis III: Interprofessional Care01:29

Venous Thrombosis III: Interprofessional Care

26
Venous thrombosis requires effective prevention and treatment strategies to improve patient outcomes and reduce potential complications.Prevention StrategiesHealthcare providers must prioritize preventing venous thromboembolism (VTE) for all adult patients upon admission. Interventions depend on bleeding and thrombosis risk, medical history, current medications, diagnoses, planned procedures, and patient preferences. Patients on bed rest should change positions every two hours and, if not...
26
Heart Failure V: Medical Management01:30

Heart Failure V: Medical Management

29
Medical Management of Acute Decompensated Heart Failure (ADHF)The primary goals of therapy for patients hospitalized with acute decompensated heart failure (ADHF) include:Relieving symptomsOptimizing volume statusSupporting oxygenation and ventilationMaintaining cardiac output (CO) and end-organ perfusionIdentifying and addressing the cause of ADHFPreventing complicationsProviding patient education on factors precipitating HF exacerbationPlanning for dischargeOngoing monitoring and assessment...
29
Hypertension IV: Drug Therapy and Lifestyle Modifications01:28

Hypertension IV: Drug Therapy and Lifestyle Modifications

48
Multiple classes of antihypertensive medications are employed in treating hypertension. The most commonly recommended first-line treatments include:Thiazide Diuretics, such as chlorthalidone, increase sodium and water excretion from the body, reducing blood volume and blood pressure.Angiotensin-converting enzyme inhibitors, like lisinopril, block the conversion of angiotensin I to II, a potent vasoconstrictor lowering blood pressure.Angiotensin II Receptor Blockers (ARBs) prevent angiotensin II...
48

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Cefazolin for Methicillin-Susceptible <i>Staphylococcus aureus</i> Bacteremia.

The New England journal of medicine·2026
Same author

Aminoglycosides induce immune activation but is insufficient for systemic viral control: a double-blind randomized-controlled clinical trial.

Communications medicine·2026
Same author

Influence of obesity on susceptibility to systemic symptoms and host responses to orthoflaviviral infection: a prospective observational study using yellow fever vaccine to simulate acute infection.

EBioMedicine·2026
Same author

Human Papillomavirus Diversity in Asian Individuals With Cutaneous Squamous Cell Carcinoma.

JAMA dermatology·2026
Same author

Addressing the elephant in the room: Proceedings of the third annual Dengue Endgame Summit.

PLoS neglected tropical diseases·2026
Same author

Neutralizing antibody titers do not predict T cell response to live-attenuated orthoflaviviral vaccination in humans.

Vaccine·2026

Related Experiment Video

Updated: Sep 16, 2025

A Murine Model of Dengue Virus-induced Acute Viral Encephalitis-like Disease
04:23

A Murine Model of Dengue Virus-induced Acute Viral Encephalitis-like Disease

Published on: April 28, 2019

6.7K

A helping hand against severe dengue.

Shirin Kalimuddin1, Eng Eong Ooi2

  • 1Department of Infectious Diseases, Singapore General Hospital, Singapore 169856, Singapore; Program in Emerging Infectious Diseases, Duke-NUS Medical School, Singapore 169857, Singapore.

Cell Host & Microbe
|July 10, 2025
PubMed
Summary
This summary is machine-generated.

Early CD4+ TEMRA cell expansion and enhanced regulatory T cell function are key immune responses protecting against severe dengue. These findings offer insights for developing effective dengue vaccines.

More Related Videos

Measuring Dengue Virus RNA in the Culture Supernatant of Infected Cells by Real-time Quantitative Polymerase Chain Reaction
08:36

Measuring Dengue Virus RNA in the Culture Supernatant of Infected Cells by Real-time Quantitative Polymerase Chain Reaction

Published on: November 1, 2018

32.1K
Author Spotlight: Development of a Smartphone-Enhanced Paper-Based Device for Rapid Dengue NS1 Detection
06:00

Author Spotlight: Development of a Smartphone-Enhanced Paper-Based Device for Rapid Dengue NS1 Detection

Published on: January 26, 2024

1.5K

Related Experiment Videos

Last Updated: Sep 16, 2025

A Murine Model of Dengue Virus-induced Acute Viral Encephalitis-like Disease
04:23

A Murine Model of Dengue Virus-induced Acute Viral Encephalitis-like Disease

Published on: April 28, 2019

6.7K
Measuring Dengue Virus RNA in the Culture Supernatant of Infected Cells by Real-time Quantitative Polymerase Chain Reaction
08:36

Measuring Dengue Virus RNA in the Culture Supernatant of Infected Cells by Real-time Quantitative Polymerase Chain Reaction

Published on: November 1, 2018

32.1K
Author Spotlight: Development of a Smartphone-Enhanced Paper-Based Device for Rapid Dengue NS1 Detection
06:00

Author Spotlight: Development of a Smartphone-Enhanced Paper-Based Device for Rapid Dengue NS1 Detection

Published on: January 26, 2024

1.5K

Area of Science:

  • Immunology
  • Virology
  • Vaccinology

Background:

  • Dengue virus infection poses a significant global health threat, causing millions of cases annually.
  • Understanding the immune mechanisms underlying protection against severe dengue is crucial for effective disease control and vaccine development.

Purpose of the Study:

  • To identify specific immune responses associated with protection from severe dengue.
  • To provide insights for the rational design of dengue vaccines.

Main Methods:

  • Analysis of immune cell populations and cytokine profiles in individuals with varying dengue severity.
  • Characterization of T cell subsets, including CD4+ TEMRA cells and regulatory T cells.
  • Assessment of type I interferon (IFN) signaling pathways in T cells.

Main Results:

  • Early expansion of CD4+ TEMRA (T effector memory cells re-expressing CD45RA) cells correlated with protection.
  • Enhanced function of regulatory T cells was observed in protected individuals.
  • Distinct type I IFN signatures were identified in T cells from protected individuals.

Conclusions:

  • Specific T cell responses, including CD4+ TEMRA cell expansion and regulatory T cell function, are critical for protection against severe dengue.
  • Type I IFN signaling in T cells may play a role in protective immunity.
  • These findings have direct implications for improving dengue vaccine strategies.