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A Murine Model of Dengue Virus-induced Acute Viral Encephalitis-like Disease
Published on: April 28, 2019
A helping hand against severe dengue
Shirin Kalimuddin1, Eng Eong Ooi2
1Department of Infectious Diseases, Singapore General Hospital, Singapore 169856, Singapore; Program in Emerging Infectious Diseases, Duke-NUS Medical School, Singapore 169857, Singapore.
Abstract:
What immune responses protect against severe dengue? In this issue of Cell Host & Microbe, Gonnella et al. find that early CD4+ TEMRA cell expansion, enhanced regulatory T cell function, and type I IFN signatures in T cells are associated with protection, offering insights with implications for dengue vaccine development.
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