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Pneumonia I: Introduction

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Related Experiment Video

Updated: Sep 16, 2025

Development of Obliterative Bronchiolitis in a Murine Model of Orthotopic Lung Transplantation

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Published on: July 10, 2012

An Unexpected Cause of Postobstructive Pneumonia.

Vanina Livi¹, Alessandra Cancellieri², Maria Chiara Flore¹

¹Division of Interventional Pulmonology, Department of Neurosciences, Sense Organs and Thorax, Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy.

|July 10, 2025

Summary

A severe airway stenosis in a former smoker with a history of lung cancer led to respiratory failure. Prompt evaluation and management are crucial for patients with complex pulmonary conditions.

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Area of Science:

Pulmonology
Interventional Pulmonology
Oncology

Background:

A 72-year-old male with a significant smoking history (60 pack-years) and prior lung cancer surgery presented with respiratory issues.
The patient had a history of squamous cell carcinoma, treated with right upper lobectomy and chemotherapy, but missed follow-up during the COVID-19 pandemic.

Observation:

The patient experienced severe stenosis of the right main stem bronchus, leading to post-obstructive pneumonia and respiratory failure.
Symptoms included persistent cough and chest tightness, with difficulty expectorating mucus plugs.

Findings:

The case highlights a complex clinical scenario involving post-obstructive pneumonia secondary to severe airway stenosis.
The patient's extensive medical history includes COPD, obesity, diabetes, myelodysplastic syndrome, and prior cancer resections.

Implications:

This case underscores the importance of timely diagnosis and management of airway stenosis, especially in patients with a history of malignancy and smoking-related lung disease.
Interventional pulmonology plays a key role in evaluating and treating such severe airway obstructions.