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![[DPEPhosbcpCu]PF6: A General and Broadly Applicable Copper-Based Photoredox Catalyst](/_next/image?url=https%3A%2F%2Fcloudfront.jove.com%2FCDNSource%2Fteasers%2F59739.jpg&w=3840&q=50)
[DPEPhosbcpCu]PF6: A General and Broadly Applicable Copper-Based Photoredox Catalyst
Published on: May 21, 2019
Arylamine Photocatalyst-Induced Addition/Cyclization of 2-Allylaminobenzonitriles with gem-Difluoromethyl Radical for
Lin Shu1, Huan Wang1, Ziqing Jian1
1Guangxi Key Laboratory of Drug Discovery and Optimization, Guangxi Engineering Research Center for Pharmaceutical Molecular Screening and Druggability Evaluation, College of Pharmacy, Guilin Medical University, Guilin 541199, China.
Abstract:
A transition metal-free photocatalytic addition/cyclization of 2-allylaminobenzonitriles with gem-difluoromethyl radicals has been developed, constructing phenanthridine derivatives in moderate to good yields. The strongly reducing arylamine was employed as a photocatalyst in the reaction, which tolerated tertiary amines and efficiently enabled the conversion of gem-difluoromethyl radical precursors into radical species. The obtained novel phenanthridine derivatives exhibited blue to green emissions at the range of 390-540 nm, showing potential application in fluorescent dye.
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