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Salvage therapy with allogeneic invariant natural killer cells in a heavily pre-treated germ cell tumor

Benjamin Garmezy1, Joseph E Grossman2, Jennifer Buell2,3

  • 1Sarah Cannon Research Institute, Nashville, TN, USA. Ben.garmezy@scri.com.

Oncogene
|July 10, 2025
PubMed

Invariant natural killer T (iNKT) cells, previously considered to be tissue-resident, are an emerging and versatile allogeneic cell therapy with potent anti-tumor activity, acting at the interplay between innate and adaptive immune responses. We report an unprecedented complete remission in a heavily pre-treated metastatic germ cell neoplasm, using ex vivo expanded allogeneic iNKT cells, warranting further trials.

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