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Published on: October 20, 2023
Cryoneurolysis: Parallel Growth in PubMed Publications and Google Trends Analysis Reveals Exponential Interest
Francois H Cornelis1,2, Rozan Bokhari3, Ruben Geevarghese3
1Department of Radiology, Memorial Sloan Kettering Cancer Center, New York, NY, 10065, USA. cornelif@mskcc.org.
Purpose:
This study analyzed global interest in cryoneurolysis, a minimally invasive nerve ablation technique for non-opioid pain management, identifying temporal trends, geographic distribution, and commercial drivers influencing adoption.
Materials And Methods:
Retrospective analysis of Google Trends data (January 2004-March 2025) and PubMed publications (1993-2025) using the keyword "cryoneurolysis." Statistical analyses included Mann-Kendall trend tests, Portmanteau white noise tests, Dickey-Fuller unit root tests, and Spearman correlations. Forecasting employed nonseasonal Holt-Winters smoothing and local polynomial regression.
Results:
Search interest remained negligible (SVI = 0) from 2004 to mid-2019, with academic activity preceding public interest by 3-4 years. Both datasets demonstrated significant upward trends (PubMed: τ = 0.80, p < 0.0001; Google Trends: τ = 0.75, p < 0.0001). Commercial driver "Iovera" showed perfect correlation (r = 1.0) with search volume. Geographic concentration was limited to six high-income countries. Forecasting projects sustained growth through 2030, with publications increasing from 46.1 (95% CI: 41.8-50.4) in 2025 to 72.6 (95% CI: 59.2-86.0) by 2030.
Conclusion:
Analysis reveals parallel academic-public interest growth driven by commercial factors, geographic concentration in developed nations, and emerging applications in interventional radiology, suggesting wider adoption by 2030.
