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Updated: Sep 16, 2025
Biosensor for Detection of Antibiotic Resistant Staphylococcus Bacteria
Published on: May 8, 2013
Prevalence of methicillin-resistant coagulase-negative staphylococci in Africa: a systematic review and meta-analysis
Tomiwa Olumide Adesoji1, Namwin Siourime Somda2,3, Patience Tetteh-Quarcoo2
1Department of Microbiology, Obafemi Awolowo University, Ile-Ife, 220005, Nigeria.
Abstract:
Coagulase-negative staphylococci (CoNS) represent a diverse group of opportunistic pathogens associated with human and animal infections. The burden of infectious diseases attributed to antibiotic-resistant CoNS, particularly methicillin-resistant CoNS (MR-CoNS), is a global public health concern. However, there is limited data on the epidemiology of MR-CoNS in Africa. This systematic review provides insights on MR-CoNS from human and non-human sources in Africa, the methicillin-resistance gene determinants and the associated mobile genetic elements. The review retrieved articles from four electronic databases: PubMed, Scopus, Web of Science, and Google Scholar, using specific keywords. This study was carried out until 20 November 2024. Articles were screened and data was extracted and analyzed following the PRISMA guidelines. The meta-analysis used the binary random effects model with a 95% confidence interval. Overall, 65 articles from 16 African countries were included in the study. The pooled prevalence rates for CoNS and MR-CoNS in Africa were 27% and 36%, respectively. The review identified 36 species of CoNS from human and non-human sources. In addition, 20 (31%) studies each reported CoNS and MR-CoNS from human and animal infections. The most prevalent species of MR-CoNS included Staphylococcus epidermidis, Staphylococcus haemolyticus, and Mammaliicoccus sciuri. The African MR-CoNS harboured different staphylococcal chromosome cassette mec (SCCmec) elements (types I, II, III, IV, V, VI, VIII, and a SCCmec-mecC (hybrid), and the most common SCCmec element was the SCCmec type IV. The findings highlight the paucity of data on the epidemiology of MR-CoNS in Africa. The identification of MR-CoNS from human and animal infections indicates the need for a detailed characterization using molecular methods. This strategy will provide data to healthcare practitioners and policymakers to develop effective measures to combat antimicrobial resistance in Africa.
Insights
Antibiotic-resistant coagulase-negative staphylococci (CoNS), especially methicillin-resistant CoNS (MR-CoNS), are a growing concern in Africa. This review reveals a 36% prevalence of MR-CoNS, underscoring the urgent need for molecular characterization and control strategies.
Area of Science:
- Microbiology
- Epidemiology
- Public Health
Background:
- Coagulase-negative staphylococci (CoNS) are opportunistic pathogens causing significant human and animal infections.
- Antibiotic resistance in CoNS, particularly methicillin-resistant CoNS (MR-CoNS), poses a global health threat.
- Data on MR-CoNS epidemiology in Africa is notably scarce.
Purpose of the Study:
- To systematically review the epidemiology of MR-CoNS in Africa.
- To identify MR-CoNS species, resistance determinants, and mobile genetic elements.
- To highlight data gaps and inform antimicrobial resistance control strategies.
Main Methods:
- Systematic review of four databases (PubMed, Scopus, Web of Science, Google Scholar) until November 2024.
- PRISMA guidelines for screening and data extraction.
- Meta-analysis using a binary random effects model (95% CI).
Main Results:
- 65 articles from 16 African countries were included.
- Pooled prevalence rates: CoNS 27%, MR-CoNS 36%.
- Prevalent MR-CoNS species: S. epidermidis, S. haemolyticus, M. sciuri.
- Commonly identified SCCmec type: IV.
- MR-CoNS identified in human and animal infections.
Conclusions:
- Significant prevalence of MR-CoNS in Africa necessitates further investigation.
- Molecular characterization of MR-CoNS is crucial for understanding transmission and resistance.
- Findings underscore the need for enhanced surveillance and targeted interventions against antimicrobial resistance in Africa.
