Nodal peripheral T-cell lymphoma in Finland between 2007 and 2019: Incidence, late morbidity and survival

Data on late morbidity and survival in nodal peripheral T-cell lymphoma (PTCL) are scarce. This study investigated the incidence, subtype distribution, late morbidity and survival outcomes of nodal PTCL in Finland. The study compared 998 patients with nodal PTCL diagnosed between 2007 and 2019 with matched controls. Data from four nationwide Finnish healthcare registries were used. PTCL not otherwise specified was the most common subtype, with a mean annual incidence of 0.62 (0.45-0.87) per 100 000. The 1-year survival was 34% for patients aged <70 years and 49% for those aged ≥70 years. In the younger group, an increased risk of chronic heart failure (hazard ratio [HR], 4.17 [2.16-8.05]; p < 0.001) was observed after PTCL diagnosis. The risks of pneumonia (HR, 6.47 [4.40-9.53]; p < 0.001 and HR, 2.78 [2.010-3.859]; p < 0.001) and thrombosis (HR, 16.09 [4.22-61.39]; p < 0.001 and HR, 5.34 [2.33 to NA]; p < 0.001) were significantly higher in the younger and older age groups than that in controls. The prognosis of nodal PTCL is poor, and patients have a significantly higher risk of comorbidities than controls, irrespective of age. Therefore, targeted and less toxic treatment modalities are required.