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Hydromorphone Hydrochloride for Postoperative Pain Relief and Safety in Children Undergoing Wilms Tumour Operation: A

Dan Yu1, Shaofei Hu2, Meijun Tian2

  • 1Department of Pediatric General Surgery, Qingdao Women and Children's Hospital, 266034 Qingdao, Shandong, China.

Archivos Espanoles De Urologia
|July 11, 2025
PubMed

Insights

Hydromorphone hydrochloride effectively manages postoperative pain in children undergoing Wilms tumour surgery, offering improved pain scores and sedation compared to morphine. This approach ensures better safety and recovery for paediatric patients.

Area of Science:

  • Paediatric Surgery
  • Pain Management
  • Pharmacology

Background:

  • Wilms tumour is the most common paediatric kidney cancer.
  • Effective postoperative pain management is crucial for recovery in children undergoing Wilms tumour surgery.

Purpose of the Study:

  • To evaluate the analgesic efficacy and safety of hydromorphone hydrochloride versus morphine hydrochloride in paediatric patients post-Wilms tumour operation.
  • To compare pain scores, vital signs, and adverse events between the two analgesic groups.

Main Methods:

  • Retrospective analysis of paediatric patients (n=154) from January 2020 to June 2024.
  • Patients received either intravenous hydromorphone hydrochloride (3 µg/kg/h) or intravenous morphine hydrochloride (15 µg/kg/h).
  • Evaluated outcomes included MAP, HR, RR, SpO2, FLACC pain scores, and RSS at multiple postoperative time points.

Main Results:

  • Hydromorphone group showed significantly lower FLACC and RSS scores at 6 and 24 hours postoperatively (p < 0.001).
  • Lower HR and RR were observed in the hydromorphone group at 6 and 24 hours (p < 0.05).
  • The hydromorphone group experienced a lower incidence of adverse reactions (p < 0.05).

Conclusions:

  • Hydromorphone hydrochloride is effective for postoperative pain management in paediatric Wilms tumour patients.
  • It demonstrates superior pain relief, sedation, and safety compared to morphine in this population.
  • Hydromorphone hydrochloride offers a promising option for enhancing recovery and ensuring safety in paediatric cancer surgery.
Abstract

Keywords:
Wilms tumourpostoperative analgesic protocolsecurity

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