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Effect of Ramadan Fasting on Malondialdehyde, Poly (ADP-Ribose) Polymerase, Sirtuin 1, Nuclear Receptor Subfamily 1 Group D Member 1, and Transforming Growth Factor Beta in Chronic Kidney Disease: A Prospective Cohort Study

  • 0Biomedical Department, Faculty of Medicine, Andalas University - M. Djamil Hospital, Padang, Indonesia.. drajadpriyono1234@yahoo.com.
Acta Medica Indonesiana +

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July 11, 2025

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July 11, 2025

View abstract on PubMed

Summary

This summary is machine-generated.

Ramadan fasting significantly impacts biochemical markers in early-stage chronic kidney disease (CKD) patients, potentially improving oxidative stress and inflammation. Further research is needed to confirm long-term clinical benefits for CKD management.

Area Of Science

  • Nephrology
  • Metabolic Research
  • Biochemistry

Background

  • Chronic kidney disease (CKD) presents a growing global health challenge.
  • Understanding the impact of lifestyle interventions like Ramadan fasting on CKD biomarkers is crucial.

Purpose Of The Study

  • To investigate the effects of Ramadan fasting on key biochemical and oxidative stress markers in patients with early-stage CKD (stages 1, 2, 3A).

Main Methods

  • A prospective cohort study involving 30 CKD patients undergoing Ramadan fasting.
  • Biomarker analysis (MDA, PARP, SIRT1, NR1D1, TGF-β, urea, glucose, HbA1C, uric acid, lipids, creatinine, albumin) using ELISA before, during, and after fasting.

Main Results

  • Significant reductions observed in urea, fasting blood glucose, HbA1C, and uric acid.
  • Decreases in MDA and SIRT1, with increases in PARP and NR1D1, suggesting modulation of oxidative stress and circadian rhythm.
  • No significant changes in lipid profiles, creatinine, or albumin.

Conclusions

  • Ramadan fasting induces notable changes in biochemical parameters and biological markers in early-stage CKD.
  • Findings suggest potential benefits for oxidative stress, autophagy, inflammation, and circadian rhythm regulation.
  • Further investigation is warranted for long-term effects and clinical applicability in CKD patient management.

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