Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Cardiomyopathy VII: Pre and Post Operative Nursing Management01:28

Cardiomyopathy VII: Pre and Post Operative Nursing Management

29
Patients with hypertrophic cardiomyopathy (HCM) and left ventricular outflow tract (LVOT) obstruction who remain symptomatic despite optimal medical therapy may undergo a septal myectomy (Morrow procedure). This procedure involves excising a portion of the hypertrophied septum below the aortic valve using a heart-lung machine to improve blood flow through the LVOT. Effective preoperative and postoperative nursing management ensures successful patient outcomes, minimizes complications, and...
29
Mitral Stenosis III: Medical Management01:26

Mitral Stenosis III: Medical Management

28
Mitral stenosis, a condition marked by the narrowing of the mitral valve, necessitates an integrated approach for effective management. This approach includes preventative measures, medical therapy, and surgical interventions to reduce symptoms and prevent complications.PreventionPrevention of mitral stenosis primarily focuses on reducing the incidence of bacterial infections, particularly streptococcal infections, which can lead to rheumatic fever and subsequent valvular damage. Timely...
28
Inflammatory Bowel Disease V: Surgical Management01:21

Inflammatory Bowel Disease V: Surgical Management

221
Surgical interventions for inflammatory bowel disease (IBD), which includes ulcerative colitis and Crohn's disease, are essential in managing symptoms and addressing complications. The selection of surgical procedures is contingent upon the specific conditions and complications that stem from these illnesses.
Here are some common surgical interventions for IBD:
221

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Fate of dilated ascending aorta after transcatheter aortic valve replacement.

JTCVS structural and endovascular·2026
Same author

A Call for Investment in Sponsorship, Apprenticeship, and Mentorship: Ensuring the Future of Congenital Heart Surgery.

The Annals of thoracic surgery·2026
Same author

Autologous adipose-derived mesenchymal stromal cells for chronic traumatic brain injury.

Brain : a journal of neurology·2026
Same author

Minimally invasive versus conventional techniques for proximal aortic surgery: A systematic review and meta-analysis of reconstructed patient-level data.

Asian cardiovascular & thoracic annals·2026
Same author

Single Ventricle Physiology May Not Preclude Cardiac Repair in the Setting of Congenital Diaphragmatic Hernia.

World journal for pediatric & congenital heart surgery·2026
Same author

Autograft Enlargement After the Ross Procedure in Pediatric Patients: Somatic Growth or Pathologic Dilatation?

World journal for pediatric & congenital heart surgery·2026

Related Experiment Video

Updated: Sep 16, 2025

Model Surgical Training: Skills Acquisition in Fetoscopic Laser Photocoagulation of Monochorionic Diamniotic Twin Placenta Using Realistic Simulators
09:51

Model Surgical Training: Skills Acquisition in Fetoscopic Laser Photocoagulation of Monochorionic Diamniotic Twin Placenta Using Realistic Simulators

Published on: March 21, 2018

19.8K

Improved Surgical Management of Complex Neonates With Heterotaxy Syndrome.

Alexander C Mills1, Ashley E Dawson1, Michael C Scott1

  • 1McGovern Medical School at UTHealth, Houston, TX, USA.

World Journal for Pediatric & Congenital Heart Surgery
|July 11, 2025
PubMed
Summary

Neonatal surgery for heterotaxy syndrome congenital heart defects (CHD) has improved. Right atrial isomerism, left atrial isomerism with single ventricle, and obstructed total anomalous pulmonary venous connection increase operative risk.

Keywords:
CHDheterotaxyneonatalsingle ventricle anatomysurgical outcomes

More Related Videos

Transuterine Fetal Tracheal Occlusion Model in Mice
06:31

Transuterine Fetal Tracheal Occlusion Model in Mice

Published on: February 5, 2021

3.2K
Hemodynamic Precision in the Neonatal Intensive Care Unit using Targeted Neonatal Echocardiography
09:31

Hemodynamic Precision in the Neonatal Intensive Care Unit using Targeted Neonatal Echocardiography

Published on: January 27, 2023

1.1K

Related Experiment Videos

Last Updated: Sep 16, 2025

Model Surgical Training: Skills Acquisition in Fetoscopic Laser Photocoagulation of Monochorionic Diamniotic Twin Placenta Using Realistic Simulators
09:51

Model Surgical Training: Skills Acquisition in Fetoscopic Laser Photocoagulation of Monochorionic Diamniotic Twin Placenta Using Realistic Simulators

Published on: March 21, 2018

19.8K
Transuterine Fetal Tracheal Occlusion Model in Mice
06:31

Transuterine Fetal Tracheal Occlusion Model in Mice

Published on: February 5, 2021

3.2K
Hemodynamic Precision in the Neonatal Intensive Care Unit using Targeted Neonatal Echocardiography
09:31

Hemodynamic Precision in the Neonatal Intensive Care Unit using Targeted Neonatal Echocardiography

Published on: January 27, 2023

1.1K

Area of Science:

  • Pediatric Cardiology
  • Congenital Heart Surgery
  • Neonatal Medicine

Background:

  • Heterotaxy syndrome presents complex congenital heart defects (CHD) with varied cardiac and visceral anatomy.
  • Neonatal management of these patients is challenging due to significant phenotypic heterogeneity.
  • Contemporary surgical outcomes and identification of high-risk substrates are crucial.

Purpose of the Study:

  • To evaluate current surgical outcomes in neonates with heterotaxy syndrome and CHD.
  • To identify specific anatomic substrates associated with increased operative risk.
  • To analyze factors influencing mortality and morbidity in this patient population.

Main Methods:

  • Retrospective evaluation of 41 heterotaxy CHD patients undergoing neonatal surgical repair/palliation over 10 years.
  • Classification of heterotaxy anatomy into right atrial isomerism (RAI) or left atrial isomerism (LAI).
  • Multivariate Cox regression and Kaplan-Meier analyses for operative and intermediate-term outcomes.

Main Results:

  • Operative mortality was 9.8%; interstage death rate was 10%.
  • Obstructed total anomalous pulmonary venous connection (TAPVC) was a significant risk factor for overall mortality (HR 6.0, P=.033).
  • Decreased five-year survival observed in RAI, LAI with single ventricle, and RAI with obstructed TAPVC.

Conclusions:

  • Cardiac surgical outcomes for neonates with heterotaxy syndrome have improved.
  • Right atrial isomerism anatomy, LAI with single ventricle physiology, and RAI with obstructed TAPVC are associated with increased operative risk.
  • Risk stratification is essential for optimizing management of these complex neonates.