Related Experiment Video
Updated: Sep 16, 2025
10:22
Humanized Mediator Release Assay as a Read-Out for Allergen Potency
Published on: June 29, 2021
3.6K
Hymenoptera anaphylaxis and mast cell activation disorders
David González-de-Olano1,2, Iván Álvarez-Twose2,3,4
1Department of Allergy, Hospital Ramón y Cajal, IRYCIS, Madrid.
Current Opinion in Allergy and Clinical Immunology
|July 11, 2025
Summary
Identifying systemic mastocytosis in hymenoptera venom allergy (HVA) patients is crucial. Specific anaphylaxis symptoms and sensitive tests aid diagnosis, impacting immunotherapy management and potential complications.
Area of Science:
- Allergy and Immunology
- Hematology
- Mast Cell Biology
Background:
- A significant subset of patients with hymenoptera venom allergy (HVA) harbor underlying systemic mastocytosis.
- Accurate identification is vital for tailored patient management and treatment strategies.
Purpose of the Study:
- To highlight the importance of recognizing clonal mast cell disease (MCD) in HVA patients.
- To discuss diagnostic indicators and management differences for HVA patients with MCD.
Main Methods:
- Review of clinical presentations of anaphylaxis post-stinging, focusing on cardiovascular and cutaneous symptoms.
- Emphasis on the need for highly sensitive techniques to detect clonality due to low mast cell burden in affected individuals.
Main Results:
- Anaphylaxis with cardiovascular symptoms and lack of cutaneous signs suggests clonal mast cell disease (MCD).
- Low mast cell burden necessitates sensitive diagnostic methods for clonality detection.
Conclusions:
- Recognizing HVA patients with clonal MCD is essential as immunotherapy protocols and treatment durations differ from the general allergic population.
- Predictive scores and appropriate diagnostic techniques can prevent unnecessary investigations.
- Patients with clonal MCD may experience complications beyond mast cell mediator release, such as bone loss, requiring specific treatment.
Related Concept Videos
02:06Allergic Reactions
28.8K
Overview
28.8K
01:25Antiasthma Drugs: Mast Cell Stabilizers and Anti-IgE Drugs
471
Asthma is a chronic respiratory condition for which new therapeutic avenues, including anti-inflammatory drugs like mast cell stabilizers and anti-IgE treatments, continue to be developed.
Mast cell stabilizers, such as cromolyn (also known as sodium cromoglycate) and nedocromil (Tilade), are effective drugs in asthma management. These stabilizers hinder histamine release by skillfully obstructing the activation of mast cells and other cellular entities. Notably, they navigate this task without...
Mast cell stabilizers, such as cromolyn (also known as sodium cromoglycate) and nedocromil (Tilade), are effective drugs in asthma management. These stabilizers hinder histamine release by skillfully obstructing the activation of mast cells and other cellular entities. Notably, they navigate this task without...
471
01:30Hypersensitivities
1.1K
Hypersensitivity, also known as a hypersensitivity reaction or allergic reaction, is a condition where the body's immune system reacts abnormally to a foreign substance. Such substances, that cause hypersensitivity are referred to as an allergen, could be something typically harmless to most people, like pollen or certain foods.
Types of Hypersensitivities
Hypersensitivity reactions are categorized into four types: Type 1, Type 2, Type 3, and Type 4. Each type has a distinct mechanism...
Types of Hypersensitivities
Hypersensitivity reactions are categorized into four types: Type 1, Type 2, Type 3, and Type 4. Each type has a distinct mechanism...
1.1K
01:26Asthma-II: Pathophysiology and Classification
2.9K
Asthma is a prevalent chronic respiratory condition marked by inflammation and hyperresponsiveness of the airways. Its pathophysiology involves complex interactions among inflammatory pathways, immune responses, and neural mechanisms.
Additionally, environmental and genetic factors play crucial roles in determining an individual's susceptibility to asthma and the severity of their condition.
Critical processes in asthma pathophysiology include:
Additionally, environmental and genetic factors play crucial roles in determining an individual's susceptibility to asthma and the severity of their condition.
Critical processes in asthma pathophysiology include:
2.9K
01:20Asthma: Pathogenesis and Management
607
Asthma is a chronic pulmonary condition involving inflammation of the airways, hyper-reactivity, and reversible obstruction of the airways. This condition can significantly impact a person's quality of life, making breathing difficult and leading to distressing symptoms.
Asthma is classified as allergic and non-allergic. Allergens such as dust mites, pollen, and pet dander trigger allergic asthma, while factors like cold air, intense emotions, or exercise can induce non-allergic asthma.
Asthma is classified as allergic and non-allergic. Allergens such as dust mites, pollen, and pet dander trigger allergic asthma, while factors like cold air, intense emotions, or exercise can induce non-allergic asthma.
607
01:27Allergic Drug Reactions
983
Allergic reactions related to drugs are hypersensitivity responses driven by the immune system and bear no connection to the drug's therapeutic action. While drugs in isolation do not trigger an immune response, they can interact with endogenous proteins to form antigens. These antigens stimulate lymphocytes to produce antibodies. IgE-type antibodies attach themselves to mast cells. Upon subsequent exposure to the same stimulus, the antigen-antibody interaction is initiated, unleashing...
983