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Assessment of Vascular Function in Patients With Chronic Kidney Disease
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Assessment of Vascular Function in Patients With Chronic Kidney Disease

Published on: June 16, 2014

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Assessing Vascular Biomarkers and Their Association with Hypertension in Paediatric Chronic Kidney Disease

Samira Z Sayed1, Engy R Mohamed1, Mohamed T A Moustafa2

  • 1Departments of Pediatrics, Faculty of Medicine, Minia University, Minia, Egypt.

Sultan Qaboos University Medical Journal
|July 11, 2025
PubMed

Insights

Children with chronic kidney disease (CKD) show higher levels of endothelial dysfunction biomarkers, including asymmetric dimethylarginine (ADMA), angiopoietin-2 (Ang-2), and vascular endothelial growth factor-A (VEGF-A). These elevated biomarkers correlate with increased cardiovascular risk in pediatric CKD patients.

Area of Science:

  • Pediatric Nephrology
  • Cardiovascular Research
  • Biomarker Discovery

Background:

  • Chronic kidney disease (CKD) in children is associated with significant cardiovascular complications.
  • Endothelial dysfunction is a key contributor to cardiovascular risk in pediatric CKD.
  • Biomarkers of endothelial dysfunction require further investigation in this population.

Purpose of the Study:

  • To investigate the correlation between chronic kidney disease (CKD) in children and specific endothelial dysfunction biomarkers.
  • To assess the relationship between these biomarkers, blood pressure, and cardiovascular risk in pediatric CKD.
  • To evaluate the potential clinical utility of these biomarkers in managing pediatric CKD.

Main Methods:

  • A case-control study involving 90 children, divided into 45 with CKD and 45 healthy controls.
  • Measurements included blood pressure and serum levels of asymmetric dimethylarginine (ADMA), angiopoietin-2 (Ang-2), and vascular endothelial growth factor-A (VEGF-A).
  • Study conducted between November 2021 and October 2022 at El-Minia University hospitals, Egypt.

Main Results:

  • Children with CKD exhibited significantly higher levels of ADMA, Ang-2, and VEGF-A compared to healthy controls.
  • Elevated biomarker levels showed a positive correlation with both systolic and diastolic blood pressure.
  • A negative association was observed between biomarker levels and estimated glomerular filtration rate (e-GFR).

Conclusions:

  • Elevated ADMA, Ang-2, and VEGF-A are associated with increased cardiovascular risk in children with CKD.
  • These biomarkers may aid in clinical evaluations for optimizing antihypertensive treatment and improving outcomes.
  • Further research into these biomarkers can enhance therapeutic strategies for pediatric CKD.
Abstract

Keywords:
Cardiovascular RiskCellsChronic Renal FailureEgyptHypertensionVascular Endothelial Growth FactorVascular Remodeling: Biomarkers

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