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A Roadmap for the Application of Convalescent Plasma and Hyperimmune Globulins in Emerging Viral Outbreaks
Aliasghar Rahimian1, Hooman Askari1, Ali Nabati1
1Department of Clinical Biochemistry, Tehran University of Medical Sciences, Tehran, Tehran Province, Iran.
Abstract:
The outbreak of COVID-19 took the world by surprise and dealt a serious blow to the global economy. Even today, few drugs against SARS-CoV-2 infection have been proven useful, and repurposing existing antiviral therapies remains a major research area in the treatment of the disease. During previous viral outbreaks, therapies using convalescent plasma and related products have repeatedly been used as empirical approaches. Rapid preparation of convalescent plasma and hyperimmune globulins (hIVIGs) makes these two treatment options useful in dealing with outbreaks of emerging diseases. The current study presents a systematic roadmap concerning the guidelines, criteria, and regulations involved in plasma transfusion and the preparation of hIVIGs applicable to possible future viral outbreaks.
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