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Acute Lung Injury in a Healthy Peripheral Blood Stem Cell Donor Following Granulocyte-colony Stimulating Factor

Nihar Desai1,2, Tommy Alfaro Moya1,2, Michele Heffering-Cardwell1

  • 1Hans Messner Allogeneic Blood and Marrow Transplant Program Division of Medical Oncology and Hematology Princess Margaret Hospital Toronto Canada.

Ejhaem
|July 11, 2025
PubMed

Granulocyte-colony stimulating factor (G-CSF) is routinely used for peripheral blood stem cells (PBSC) mobilization in healthy donors for allogeneic hematopoietic stem cell transplantation, with mild, transient adverse effects. Pulmonary complications are exceedingly rare in healthy donors. We report a case of acute lung injury in a healthy donor after G-CSF administration requiring hospitalization and treatment with corticosteroids. This case highlights the potential for rare but serious G-CSF-induced pulmonary toxicity, particularly in donors with predisposing factors such as obesity and smoking. Increased awareness of these rare adverse events is essential given the widespread use of G-CSF in PBSC mobilization.

Keywords:
allogeneic stem cell transplantation | G‐CSF | obesity | pulmonary toxicity | stem cell donor

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