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Published on: May 28, 2019
Neuroprotective effect of intravenous lipid emulsion after bupivacaine-induced cardiac toxicity
Mevlüt Doğukan1, Nezir Yılmaz1, Ahmet Türk2
1Department of Anesthesiology and Reanimation, Faculty of Medicine, Adıyaman University, Adıyaman, Turkey.
Background:
This study aimed to investigate the protective effects of intravenous lipid emulsion (ILE) against bupivacaine-induced cardiac toxicity, using histopathological analyses.
Methods:
Twenty-eight adult male Wistar-Albino rats were divided into four groups: Sham (Group A), ILE (Group B), Bupivacaine (Group C), and Bupivacaine + ILE (Group D). Neurotoxicity was induced in Groups C and D with continuous bupivacaine infusion. ILE was administered to Groups B and D. Histological examination of brain tissues, and apoptotic index were evaluated.
Results:
The apoptotic index was significantly higher in Group C, but ILE administration in Group D markedly decreased these parameters (P < 0.05). Histopathological analysis revealed that ILE reduced edema and neuronal degeneration in Group D.
Conclusion:
ILE demonstrated a neuroprotective effect against bupivacaine-induced cardiac toxicity by improving hemodynamic stability and reducing cellular damage. This suggests a potential therapeutic role of ILE in managing local anesthetic systemic toxicity.
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