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Chronic bowel diseases are a group of long-term conditions affecting the digestive tract, characterized by inflammation and damage to the gut lining. These conditions primarily include irritable bowel syndrome and inflammatory bowel disease.
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Introduction
Inflammatory bowel disease, commonly known as IBD, refers to a collection of disorders that lead to persistent inflammation of the gastrointestinal tract. The two types of IBD are ulcerative colitis, which impacts the colon, and Crohn's disease, which can involve any part of the gastrointestinal segment.
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  1. Home
  2. Acute Inflammatory Ascites Complicating Clostridium Difficile Colitis.
  1. Home
  2. Acute Inflammatory Ascites Complicating Clostridium Difficile Colitis.

Related Experiment Video

Cefoperazone-treated Mouse Model of Clinically-relevant Clostridium difficile Strain R20291
06:51

Cefoperazone-treated Mouse Model of Clinically-relevant Clostridium difficile Strain R20291

Published on: December 10, 2016

12.7K

Acute Inflammatory Ascites Complicating Clostridium difficile Colitis.

George S Zacharia1, Shivani Jani1, Manjola Doda1

  • 1Internal Medicine, BronxCare Health System, New York, USA.

Cureus
|July 11, 2025

View abstract on PubMed

Summary
This summary is machine-generated.

Clostridium difficile (CD) infection can cause ascites, a rare complication. Treating the colitis effectively resolved the ascites in this case.

Keywords:
ascitesclostridium difficle infectioncolitisdiarrheaserum-ascites albumin gradient

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A Protein Microarray Assay for Serological Determination of Antigen-specific Antibody Responses Following Clostridium difficile Infection
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Area of Science:

  • Gastroenterology
  • Infectious Diseases
  • Internal Medicine

Background:

  • Clostridium difficile (CD) infection is a common cause of infectious diarrhea.
  • Ascites is an infrequent but serious complication of severe CD colitis.
  • The pathogenesis of ascites in CD colitis is not fully understood.

Observation:

  • A middle-aged woman with opioid overdose developed severe CD colitis.
  • She presented with ascites characterized by low serum-ascites albumin gradient (SAAG), high protein, and neutrophil predominance.
  • No colonic perforation or alternative cause for ascites was identified.

Findings:

  • Treatment with oral vancomycin and intravenous metronidazole resolved both the CD colitis and the ascites.
  • This case demonstrates an atypical presentation of CD infection.

Implications:

  • Recognizing uncommon manifestations of CD is crucial for timely diagnosis and management.
  • Treatment of the underlying CD colitis appears to be sufficient for resolving associated ascites.
  • Further research may elucidate the specific mechanisms driving ascites in CD colitis.