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Updated: Sep 16, 2025
Robot-assisted Total Mesorectal Excision and Lateral Pelvic Lymph Node Dissection for Locally Advanced Middle-low Rectal Cancer
Published on: February 12, 2022
Association Between Mesorectal Grade and Oncologic Outcomes in Rectal Cancer: A Systematic Review and Meta-Analysis
Peter Rogers1, Justin Dourado1,2, Sameh Hany Emile1,3
1Ellen Leifer Shulman and Steven Shulman Digestive Disease Center, Cleveland Clinic Florida, Weston, Florida, USA.
Abstract:
We aimed to clarify the impact of TME grading on recurrence and survival. PubMed and Scopus were searched. The main outcome measures were local and distant recurrence and overall survival. Ten studies (2002-2023) were analyzed. Patients with incomplete TME exhibited lower overall survival (HR 0.75, p = 0.044) and higher local (RR 3.09, p = 0.001) and distant (RR 1.44, p = 0.005) recurrence rates compared to complete/near-complete TME. Complete and near-complete TME had similar risk of local recurrence, distant metastasis, and overall survival. This meta-analysis supports the crucial role of TME in rectal cancer outcomes.
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