Related Experiment Video

Updated: Sep 16, 2025

A Mouse Model to Evaluate the Long-Term Structural and Functional Outcomes after the Reversal of Prolonged Unilateral Ureteric Obstruction
05:34

A Mouse Model to Evaluate the Long-Term Structural and Functional Outcomes after the Reversal of Prolonged Unilateral Ureteric Obstruction

Published on: July 18, 2025

157

Bidirectional two-sample Mendelian randomization analysis reveals a causal effect of chronic pain on chronic kidney

Chengwei Wu, Qiankun Zhang, Zhenhua Wu

    Clinical Nephrology
    |July 11, 2025
    PubMed

    Insights

    Multisite chronic pain (MCP) is linked to increased chronic kidney disease (CKD) risk and declining kidney function. This study used Mendelian randomization to explore the causal relationship between chronic pain and CKD, finding a significant association for MCP.

    Area of Science:

    • Nephrology
    • Genetics
    • Epidemiology

    Background:

    • Chronic pain and chronic kidney disease (CKD) are prevalent conditions with established correlations.
    • The causal relationship between CKD and chronic pain remains incompletely understood.
    • Investigating genetic links can elucidate potential causal pathways.

    Purpose of the Study:

    • To investigate the potential causal link between chronic kidney disease (CKD) or renal function and chronic pain.
    • To differentiate the impact of various chronic pain phenotypes on kidney health.

    Main Methods:

    • Bidirectional two-sample Mendelian randomization (MR) analyses were performed.
    • Genome-wide association study (GWAS) datasets were utilized for chronic pain phenotypes and kidney function markers.
    • Data included chronic widespread musculoskeletal pain (CWP), multisite chronic pain (MCP), estimated glomerular filtration rate (eGFRcrea), and eGFRcys.

    Main Results:

    • Multisite chronic pain (MCP) showed a significant association with an increased risk of CKD (OR = 1.52) and decline in cystatin C-based GFR (eGFRcys) (OR = 0.97).
    • No significant association was found between chronic widespread musculoskeletal pain (CWP) and CKD or renal function decline.
    • The study did not identify a causal link between renal function decline or CKD and chronic pain in the reverse direction.

    Conclusions:

    • Multisite chronic pain (MCP) is associated with a higher risk of developing chronic kidney disease (CKD) and experiencing renal function deterioration.
    • The findings highlight the importance of considering pain status in the management of kidney disease.
    Abstract

    More Related Videos

    Using 2-Photon Microscopy to Quantify the Effects of Chronic Unilateral Ureteral Obstruction on Glomerular Processes11:47

    Using 2-Photon Microscopy to Quantify the Effects of Chronic Unilateral Ureteral Obstruction on Glomerular Processes

    Published on: March 4, 2022

    2.4K
    A Large Animal Model for Acute Kidney Injury by Temporary Bilateral Renal Artery Occlusion09:02

    A Large Animal Model for Acute Kidney Injury by Temporary Bilateral Renal Artery Occlusion

    Published on: February 2, 2021

    4.6K

    Related Concept Videos

    Chronic Kidney Disease II: Clinical Manifestations01:24

    Chronic Kidney Disease II: Clinical Manifestations

    Chronic Kidney Disease (CKD) progressively impairs multiple body systems due to the accumulation of uremic toxins, which disrupt cellular functions across various organs.Neurologic symptomsNeurologic symptoms often arise early in CKD, as uremic toxin buildup drives changes in cognitive and motor functions. Patients frequently experience fatigue, headache, confusion, difficulty concentrating, and, in severe cases, seizures. Peripheral neuropathy commonly manifests as burning sensations in the...
    104
    Chronic Kidney Disease I: Introduction01:25

    Chronic Kidney Disease I: Introduction

    Chronic Kidney Disease (CKD) arises when the kidneys progressively lose their ability to function, ultimately leading to end-stage renal disease. At this advanced stage, the kidneys can no longer filter waste or maintain essential body functions, requiring renal replacement therapy (RRT) through dialysis or a kidney transplant for survival.Early-stage chronic kidney disease and detection challengesIn CKD's early stages, symptoms often remain absent because healthy nephrons compensate for...
    76
    Acute Kidney Injury II: Pathophysiology01:29

    Acute Kidney Injury II: Pathophysiology

    Acute kidney injury (AKI) causes are categorized into three primary categories based on the location of the injury: prerenal, intrarenal (or intrinsic), and postrenal causes. This classification guides clinical management and illustrates how different pathways can impair kidney function.Etiology and Pathophysiology of Acute Kidney Injury1. Prerenal causesEtiology: Prerenal Acute Kidney Injury, the most common type, occurs when reduced blood flow to the kidneys decreases filtration capacity...
    92
    Acute Kidney Injury IV: Diagnostic Studies and Prevention01:30

    Acute Kidney Injury IV: Diagnostic Studies and Prevention

    Accurate diagnosis and effective prevention are critical in managing Acute Kidney Injury (AKI), which is linked to high mortality rates ranging from 10% to 80%. Timely recognition of at-risk patients and careful monitoring can significantly reduce the likelihood of kidney damage.Diagnostic Assessments:The diagnostic process starts with a comprehensive medical history to identify prerenal, intrarenal, and postrenal causes.Prerenal causes, such as dehydration, hypotension, or blood loss, should...
    59
    Chronic Kidney Disease III: Interprofessional Care01:28

    Chronic Kidney Disease III: Interprofessional Care

    Chronic kidney disease (CKD) requires collaborative and comprehensive management. CKD progresses through stages and can lead to end-stage kidney disease (ESKD) if untreated. Interprofessional collaboration and patient education are crucial, enabling patients to manage their health and improve their quality of life.Diagnostic approach for chronic kidney diseaseThe diagnosis of CKD primarily focuses on the glomerular filtration rate (GFR), which assesses kidney function by measuring how well...
    82
    Randomized Experiments01:13

    Randomized Experiments

    The randomization process involves assigning study participants randomly to experimental or control groups based on their probability of being equally assigned. Randomization is meant to eliminate selection bias and balance known and unknown confounding factors so that the control group is similar to the treatment group as much as possible. A computer program and a random number generator can be used to assign participants to groups in a way that minimizes bias.
    Simple randomization
    Simple...
    7.3K