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Microbial growth control refers to various methods employed to inhibit, reduce, or eliminate microorganisms to ensure safety and hygiene across different settings. These methods are categorized based on the target environment and the level of microbial control required.Biocides are versatile agents designed to control microorganisms by either inhibiting their growth or outright killing them. These agents work through various physical, chemical, mechanical, or biological mechanisms. The...
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Reduced carbohydrate complexity alters gut microbial structure independent of total carbohydrate intake.

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Straining to define a healthy microbiome.

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The human gut microbiome influences disease development. Understanding microbial community interactions and functional changes is key to translating microbiome research into effective gut microbiome therapies.

Keywords:
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Area of Science:

  • Microbiology
  • Gastroenterology
  • Translational Medicine

Background:

  • The human gut microbiome plays a significant role in health and disease.
  • Early research highlighted the importance of considering the existing microbial community for microbiota manipulation and functional changes independent of composition.
  • Approved microbiota-based therapeutics demonstrate the potential of microbiome interventions.

Purpose of the Study:

  • To review progress in microbiome research over the past decade.
  • To expand on key questions that can accelerate the translation of microbiome research into therapies.
  • To discuss historical and recent advancements in understanding the microbiome's role in disease.

Main Methods:

  • Literature review of seminal and recent studies in the human gut microbiome field.
  • Analysis of the translation of mechanistic microbiome studies into therapeutic applications.
  • Discussion of two major questions critical for advancing microbiome-based therapies.

Main Results:

  • The field of microbiome research has advanced significantly, impacting disease development understanding.
  • Two microbiota-based therapeutics for Clostridioides difficile infection have been approved.
  • Translating mechanistic microbiome insights into clinical therapies remains a challenge.

Conclusions:

  • Further research addressing key questions is needed to enhance the translation of microbiome research into effective therapies.
  • Considering the extant microbial community and functional dynamics is crucial for successful microbiome interventions.
  • The microbiome holds significant therapeutic potential for various diseases, requiring continued investigation and development.