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Interocular Differences in Retinal Curvature in Anisometropic Patients and Their Association With Myopic Degree
Gongpeng Sun1,2, Muga Emu1, Rong Lin3
1Department of Ophthalmology, West China Hospital, Sichuan University, Chengdu, China.
Investigative Ophthalmology & Visual Science
|July 11, 2025
Summary
Anisometropic eyes show distinct retinal curvature changes: the more myopic eye has a steeper macula and flatter periphery. These regional differences correlate with axial length and refractive error disparities.
Area of Science:
- Ophthalmology
- Biomedical Engineering
- Retinal Imaging
Background:
- Anisometropia, a common refractive error, involves unequal refractive power between eyes.
- Understanding the ocular biomechanics in anisometropia is crucial for myopia progression research.
Purpose of the Study:
- To investigate regional differences in Gaussian retinal curvature (RC) between fellow eyes of anisometropic patients.
- To explore associations between interocular RC disparities and myopic parameter differences.
Main Methods:
- Cross-sectional study of 121 anisometropic patients using ultra-widefield swept-source optical coherence tomography.
- Three-dimensional retinal morphology reconstruction to derive Gaussian RC, segmented into macular, peripheral, and annular regions (I-VI).
- Statistical analysis included paired t-tests, Wilcoxon signed-rank tests, and Spearman correlation.
Main Results:
- The more myopic eye exhibited significantly steeper macular RC (P < 0.001) and flatter peripheral RC (P < 0.001).
- Macular/peripheral RC disparities correlated significantly with spherical equivalent (SE) and axial length (AL) differences (P < 0.05).
- Region-specific analysis showed positive correlations between AL and RC I-III, and inverse correlations for RC V-VI (P < 0.01).
Conclusions:
- Anisometropic eyes display biomechanical divergence during axial elongation.
- Macular steepening and peripheral flattening in the more myopic eye suggest region-dependent retinal adaptation mechanisms.
