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[The effect of PSMA PET/CT performed in primary staging on the clinical decision]

  • 0Urogenitális Tumorok és Klinikai Farmakológiai Osztály, Országos Onkológiai Intézet, Budapest, Hungary. kuronya.zsofia@oncol.hu.
Magyar Onkologia +

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July 11, 2025

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July 11, 2025

View abstract on PubMed

Summary

This summary is machine-generated.

Positron emission tomography/computed tomography (PET/CT) using 18F-JK-PSMA-7 in high-risk prostate cancer staging identified distant metastasis in 20 patients, guiding treatment decisions for 13 individuals. This imaging approach aids in personalized prostate cancer therapy.

Area Of Science

  • Nuclear medicine imaging
  • Oncologic imaging
  • Prostate cancer diagnostics

Context

  • High-risk prostate cancer requires accurate staging for effective treatment planning.
  • Conventional imaging may not always detect distant metastases in these patients.
  • 18F-JK-PSMA-7 PET/CT is an emerging imaging modality for prostate cancer.

Purpose

  • To evaluate the impact of 18F-JK-PSMA-7 PET/CT on primary treatment planning in high-risk prostate cancer.
  • To assess the detection rate of distant metastasis using 18F-JK-PSMA-7 PET/CT.
  • To analyze how PET/CT findings alter therapeutic strategies.

Summary

  • A retrospective analysis of 74 high-risk prostate cancer patients undergoing 18F-JK-PSMA-7 PET/CT for primary staging was performed.
  • Distant metastasis was confirmed in 20 patients (27%).
  • PET/CT results led to a change in treatment plan for 13 patients, shifting from local to systemic therapy due to detected distant or lymph node metastases.

Impact

  • 18F-JK-PSMA-7 PET/CT can identify distant metastases not detected by conventional imaging.
  • The findings influence treatment decisions, potentially avoiding ineffective local therapies.
  • Wider adoption of PSMA PET/CT in primary staging may enable more precise, personalized treatment for high-risk prostate cancer.

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