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"Unraveling EMILIN-1: A Multifunctional ECM Protein with Tumor-Suppressive Roles" Mechanistic Insights into Cancer

Samanta Muzzin1, Enrica Timis1, Roberto Doliana1

  • 1Molecular Oncology Unit, Centro di Riferimento Oncologico Aviano (CRO), Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS), 33081 Aviano, Italy.

Cells
|July 11, 2025
PubMed
Summary

Elastin Microfibril Interface Located Protein 1 (EMILIN-1) exhibits tumor-suppressive functions by regulating cell proliferation and the tumor microenvironment. Reduced EMILIN-1 expression correlates with cancer progression, highlighting its therapeutic potential.

Keywords:
extracellular matrixinflammationlymphatic vesselsneutrophil elastaseproteolytic remodelingtumor microenvironment

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