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What Does Neuroimaging Indicate in Excoriation (Skin-Picking) Disorder?

Murad Atmaca¹, Muhammed Fatih Tabara

¹From Department of Psychiatry, School of Medicine, Firat University (Drs. Atmaca and Tabara).

Harvard Review of Psychiatry

|July 11, 2025

Summary

This summary is machine-generated.

Skin-picking disorder (SPD) involves recurrent skin picking leading to tissue damage. Neuroimaging reveals distinct brain structure and function differences in patients, particularly in impulse control and motor circuits.

Keywords:

MRI excoriation fMRI neuroimaging skin-picking disorder

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Area of Science:

Neuroscience
Psychiatry
Neuroimaging

Background:

Skin-picking disorder (SPD) is characterized by repetitive, excessive skin picking causing tissue damage.
The disorder's impact on brain function and structure is increasingly recognized.

Purpose of the Study:

To review neuroimaging and neurocognitive findings related to the pathophysiology of SPD.
To elucidate the structural and functional brain differences associated with SPD.

Main Methods:

Review of neuroimaging and neurocognitive studies on SPD.
Analysis of functional imaging data (e.g., hypoactivity in specific brain regions).
Examination of structural MRI data (e.g., brain volume, cortical thickness).

Main Results:

Impairments in frontostriatal circuits are critical to SPD development.
Abnormalities in motor control circuits are linked to impulsivity and motor issues in SPD.
Functional imaging shows hypoactivity in the anterior cingulate cortex, dorsal striatum, and medial frontal areas.
Structural changes include reduced brain volume and cortical thickness in frontal impulse control regions.

Conclusions:

SPD exhibits distinct neurobiological and neuroanatomical features.
Frontostriatal and motor control circuits are implicated in SPD pathophysiology.
Further research is essential to fully understand the underlying mechanisms of SPD.