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LncRNA-Histone Modification Crosstalk: Orchestrating Cancer Pathobiology
Saade Abdalkareem Jasim1, Harikumar Pallathadka2, Ahmed Hjazi3
1Medical Laboratory Techniques Department, College of Health and Medical Technology, University of Al-Maarif, Anbar, Iraq. saad.a.j.anbar@gmail.com.
Naunyn-Schmiedeberg'S Archives of Pharmacology
|July 11, 2025
Summary
Long noncoding RNAs (lncRNAs) and histone modifications are crucial epigenetic regulators in cancer. Their crosstalk influences tumor development, offering potential for new diagnostic biomarkers and precision cancer therapies.
Area of Science:
- Epigenetics
- Cancer Biology
- Molecular Oncology
Background:
- Long noncoding RNAs (lncRNAs) and histone modifications are key epigenetic regulators in cancer.
- Histone modifications (methylation, acetylation, phosphorylation, ubiquitination) impact chromatin structure and gene expression.
- lncRNAs function via signaling, scaffolding, decoying, and guiding to alter cellular pathways.
Purpose of the Study:
- To review the intricate crosstalk between lncRNAs and histone modifications in cancer.
- To highlight the role of this crosstalk in tumor initiation and progression.
- To explore the clinical implications for diagnostics, prognostics, and therapeutics.
Main Methods:
- Literature review of lncRNA-histone modification interactions in cancer.
- Analysis of lncRNA recruitment of histone-modifying enzymes.
- Examination of specific lncRNAs (HOTAIR, MALAT1, LINC00152, SNHG1) in cancer pathobiology.
Main Results:
- lncRNAs recruit histone-modifying enzymes to regulate gene expression.
- Abnormal lncRNA expression is linked to tumor initiation, progression, and metastasis.
- lncRNA-histone modification crosstalk presents opportunities for biomarkers and therapies.
Conclusions:
- lncRNAs and histone modifications are vital epigenetic players in cancer.
- Dysregulated lncRNA-histone interactions drive tumorigenesis.
- Targeting these interactions offers promising avenues for precision oncotherapy.
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