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Comparison of 18 F-NOTA-NFB and 11 C-Methionine PET/MRI in Detecting Glioma Recurrence

Zhenwei Du^1,2, He Long¹, Yi Luo¹

¹Departments of Nuclear Medicine.

Clinical Nuclear Medicine

|July 11, 2025

Abstract:

A 37-year-old woman with recurrent glioblastoma in the right temporo-occipital lobe after surgery exhibited contrast-enhanced foci on contrast-enhanced MRI, with mild tracer uptake on 11 C-methionine PET/MRI and significantly increased tracer uptake on 18 F-NOTA-NFB, an 18 F-labeled chemokine receptor-4-targeted PET tracer, PET/MRI. 18 F-NOTA-NFB PET showed a significantly higher tumor-to-background ratio for recurrence than 11 C-methionine PET, allowing a more precise visualization of recurrent lesions. This case indicates that 18 F-NOTA-NFB PET/MRI might give advantages in glioma delineation that might provide valuable information for making a treatment strategy and personalized radiotherapy planning.

Keywords:

CXCR4 PET/MRI glioma recurrence

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