Related Experiment Video
Updated: Sep 16, 2025
Cryosectioning and Immunostaining Mouse Inner Ear Tissue: From Embryonic to Adult Stages
Published on: April 11, 2025
The impact of type 1 diabetes mellitus on hearing function in children: A systematic review
Saransh Jain1, Chetak K B2, Sanjana Singh3
1AIISH, Mysuru, India.
Objectives:
Type 1 diabetes mellitus (T1DM) is associated with neuropathy, retinopathy, and nephropathy. However, its effect on hearing in children is not explicitly explored. This systematic review specifically focused on the hearing abilities of children with T1DM.
Methods:
PubMed, Science Direct, and Scopus databases were searched for 20 years (January 2004-December 2024), following the guidelines outlined in the Preferred Reporting Items for Systematic Reviews and Meta-Analyses criteria. Two independent reviewers screened, selected, and extracted data. The Joanna Briggs Institute Critical Appraisal Tools for Analytical Cross-Sectional and Case-Control Studies were utilized to assess the quality and conduct a risk of bias analysis on the eligible studies.
Results:
After screening 1784 studies, 12 met the inclusion criteria for the review on the impact of T1DM on hearing function in children. A total of 1143 children aged 4-18 years were analysed across these 12 studies. The findings were heterogeneous, with some studies reporting elevated pure tone thresholds (particularly at mid to high frequencies), reduced otoacoustic emission amplitudes, and delayed auditory brainstem response latencies, while others showed no significant auditory differences between T1DM and control groups. Further, longer disease duration (more than 5 years), poor glycaemic control, and diabetes induced micro-vascular changes were associated with increased auditory deficits in several studies.
Conclusion:
This systematic review shows a potential association between T1DM and hearing impairment and highlights the importance of risk-based audiological monitoring in paediatric diabetic populations. While the evidence does not support universal screening, targeted evaluations for high-risk individuals (e.g., those with poor glycaemic control or longer disease duration) may enable earlier detection and intervention. Regular monitoring can help in the early detection of hearing loss so that timely support can be provided, leading to better language skills, school performance, and overall quality of life for children.
Registration:
Registered in PROSPERO (CRD42024625363).
More Related Videos
06:46A High-Throughput Multiplexed Screening for Type 1 Diabetes, Celiac Diseases, and COVID-19
Published on: July 5, 2022
14:05Behavioral Assessment of Hearing in 2 to 4 Year-old Children: A Two-interval, Observer-based Procedure Using Conditioned Play-based Responses
Published on: January 23, 2017
Related Concept Videos
01:22Diabetes Mellitus: Overview and Type I Subtype
Type 1 diabetes is an autoimmune disease in which the immune system mistakenly attacks and destroys the insulin-producing beta cells in the pancreas. As a result, the body is unable to produce sufficient insulin, and individuals with...
01:22Diabetes Mellitus: Type 2 and Gestational
01:15Diabetes: Symptoms, Diagnosis, and Complications
01:20Pathophysiology of Diabetes
Type 1 diabetes is characterized by autoimmune-mediated destruction of pancreatic β cells, with environmental factors potentially triggering this process in genetically susceptible individuals. Despite many not having a family history, certain genes increase susceptibility,...
01:36Carbohydrate Metabolism
Starch accounts for approximately 60% of the carbohydrates consumed by humans. Since amylase enzymes cannot function in the stomach's acidic environment, starch can only be digested in the mouth and small intestine. Simple sugars are found naturally in milk and fruits in...
01:16Insulin: Dosing Regimen and Adverse Effects
The basal dose constitutes about 40%-50% of the total daily dose, with the rest as premeal insulin. The mealtime insulin dose should mirror...