Living with chemotherapy-induced peripheral neuropathy: A qualitative meta-synthesis of patient experiences

To aggregate, interpret, and synthesize findings from qualitative studies on patients' experiences with chemotherapy-induced peripheral neuropathy (CIPN).

A qualitative metasynthesis was conducted following the thematic synthesis approach of Thomas & Harden. A systematic literature search was performed in MEDLINE, CINAHL, Psychology and Behavioral Sciences Collection, and Scopus, including studies published up to December 2024. Two researchers independently conducted the screening and data extraction. They also independently evaluated the quality of the included studies. The data from these studies were then thematically analyzed and synthesized using Dorothea Orem's model.

Eighteen studies were included. Four main categories were identified: (1) Physical and Functional Impact of CIPN, (2) Emotional and Psychological Impact, (3) Coping Strategies and Self-management, and (4) Support and Barriers to Health. The findings revealed distinct self-care deficits related to functional limitations, emotional distress, and coping challenges. Utilizing Orem's Nursing Theory of Self-Care Deficit, these deficits were mapped onto different levels of nursing intervention, ranging from compensatory support to educational and self-management strategies, emphasizing an action-oriented approach in patient care.

This metasynthesis highlights the complex and multidimensional effects of peripheral neuropathy on the lives of cancer patients. Applying Orem's model underscores the critical role of nurses in addressing healthcare system gaps, functional impairments, and long-term adaptation challenges to enhance supportive care for individuals suffering from CIPN.