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Targeting serotonin transporter boosts tumor-fighting T cells

Michael D Gershon1

  • 1Department of Pathology and Cell Biology, Vagelos College of Physicians and Surgeons, Columbia University, 630 West 168(th) Street, New York, NY 10032, USA.

Cell
|July 11, 2025
PubMed
Summary

Autocrine serotonin receptor activation on tumor-infiltrating CD8+ T cells boosts antitumor immunity. Repurposing depression drugs like SSRIs may offer novel cancer immunotherapy strategies.

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