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Related Experiment Video

Updated: Sep 16, 2025

Sequencing Small Non-coding RNA from Formalin-fixed Tissues and Serum-derived Exosomes from Castration-resistant Prostate Cancer Patients

Sequencing Small Non-coding RNA from Formalin-fixed Tissues and Serum-derived Exosomes from Castration-resistant Prostate Cancer Patients

Published on: November 19, 2019

Elevating prostate cancer diagnostics through extracellular vesicle miRNAs.

Marianna Kruithof-de Julio¹

¹Department for BioMedical Research, Urology Research Laboratory, University of Bern, Bern, Switzerland; Translational Organoid Models, Department for BioMedical Research, University of Bern, Bern, Switzerland; Department of Urology, Inselspital, Bern University Hospital, Bern, Switzerland.

|July 11, 2025

Summary

Extracellular vesicle-derived microRNAs (EV-miRNAs) show greater promise than cell-free microRNAs (cf-miRNAs) for prostate cancer diagnostics. Specific EV-miRNAs, like miR-375-3p and miR-1290-3p, offer high accuracy and stability for early detection.

Area of Science:

Oncology
Molecular Biology
Biochemistry

Background:

Prostate cancer diagnosis relies on PSA levels, which can be inconclusive.

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