Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Aneurysm I: Introduction01:30

Aneurysm I: Introduction

28
An aortic aneurysm is a localized outpouching or dilation at a weak point in the artery wall. It may involve different parts of the aorta, such as the abdominal aorta, aortic arch, or thoracic aorta.Etiological factorsSeveral disorders are associated with aortic aneurysms.Congenital causes, such as primary connective tissue disorders like Marfan syndrome, impact the integrity and strength of connective tissues, notably affecting the aorta. Marfan syndrome is a genetic disorder that specifically...
28
Aneurysm III: Interprofessional Care01:26

Aneurysm III: Interprofessional Care

29
Aneurysm management involves either conservative medical therapy or surgical intervention, depending on the size and symptoms of the aneurysm. Conservative management is generally reserved for smaller, asymptomatic aneurysms, while larger or symptomatic aneurysms often necessitate surgical repair.Conservative Medical TherapyFor small, asymptomatic aneurysms, particularly abdominal aortic aneurysms (AAA) less than 5.5 centimeters in diameter, conservative medical therapy is recommended. This...
29
Aneurysm II: Clinical Manifestations and Diagnostic Studies01:21

Aneurysm II: Clinical Manifestations and Diagnostic Studies

25
Thoracic, aortic arch and abdominal aneurysms are significant vascular conditions that can present with various clinical manifestations and lead to serious complications. Understanding these manifestations and the appropriate diagnostic studies is essential for effective management and treatment.Thoracic Aortic AneurysmsThoracic aortic aneurysms often remain asymptomatic until they reach a size that impinges on adjacent structures. They typically cause deep, diffuse chest pain that radiates to...
25
Aortic Regurgitation I: Introduction01:15

Aortic Regurgitation I: Introduction

42
IntroductionAortic regurgitation is characterized by the backward flow of blood from the aorta into the left ventricle during diastole and arises from the improper closure of the aortic valve. This condition results in left ventricular volume overload and can stem from both acute and chronic etiologies, each contributing uniquely to the disease's progression and symptomatology.Acute and Chronic CausesAcute aortic regurgitation often results from events that suddenly impair the integrity of the...
42
Arteries of the Head and Neck01:26

Arteries of the Head and Neck

1.8K
The human body's intricate network of arteries ensures that every organ system receives the necessary oxygen and nutrients for optimal function. The arterial network in the head and neck region is particularly complex, providing vital blood flow to the brain, eyes, and other critical structures. Prominent arteries in this region include the internal carotid arteries and the vertebral arteries.
The internal carotid arteries supply blood to the anterior portion of the cerebrum. They enter the...
1.8K
Atherosclerosis I: Introduction01:30

Atherosclerosis I: Introduction

92
Atherosclerosis is a progressive disorder characterized by the buildup of plaques on the arterial inner wall, causing them to narrow and harden over time. These plaques comprise lipids, calcium, blood components, carbohydrates, and fibrous tissue. The process primarily affects the intima of large and medium-sized arteries, reducing blood flow in any artery.Etiology and risk factorsThe cause of atherosclerosis is multifactorial, involving a complex interplay among endothelial injury, lipid...
92

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Berbamine sensitizes hepatocellular carcinoma to chemotherapy by inhibiting autophagy <i>via</i> modulating SIRT1-mediated acetylation.

Frontiers in pharmacology·2026
Same author

T lymphocyte regulatory cytokines predict frailty in older adults.

bioRxiv : the preprint server for biology·2026
Same author

ANGPT2/Tie2 Enhances H3K18la-Mediated Macrophage M2 Polarization to Promote Endothelial Cell Proliferation in the Chronically Ischaemic Brain.

CNS neuroscience & therapeutics·2026
Same author

Causal inference-based analysis of critical design features for right-turn crashes at signalized intersections.

Accident; analysis and prevention·2026
Same author

Nanoconfinement Enhances Electrochemical Oxidation in Saline Wastewater Treatment.

Environmental science & technology·2026
Same author

Multimodal graph neural networks in healthcare: a review of fusion strategies across biomedical domains.

Frontiers in artificial intelligence·2026
Same journal

Unilateral Biportal Endoscopic Decompression for Symptomatic Lumbar Stenosis Associated with Degenerative Scoliosis in Elderly Patients.

World neurosurgery·2026
Same journal

A protected microknife system for safe and ergonomic dural incision in endoscopic endonasal surgery: a technical note.

World neurosurgery·2026
Same journal

The Complementary Role of Size and Morphology in Predicting Intracranial Aneurysm Rupture: An Intra-Patient Matched Study.

World neurosurgery·2026
Same journal

Clinical Efficacy of Onyx Embolization in the Treatment of Distal Intracranial Microaneurysms.

World neurosurgery·2026
Same journal

Long-term Survival Rates in U.S. Veterans Shunted for iNPH: A Focused Analysis of Radiological Predictors.

World neurosurgery·2026
Same journal

Effects of Teriparatide on Complications and Surgical Outcomes in Patients Undergoing Correction of Adult Spinal Deformity: A Retrospective Cohort Study and Cost-Effectiveness Analysis.

World neurosurgery·2026
See all related articles

Related Experiment Video

Updated: Sep 16, 2025

Pre-Chiasmatic, Single Injection of Autologous Blood to Induce Experimental Subarachnoid Hemorrhage in a Rat Model
09:14

Pre-Chiasmatic, Single Injection of Autologous Blood to Induce Experimental Subarachnoid Hemorrhage in a Rat Model

Published on: June 18, 2021

2.5K

Pathophysiological Mechanisms for Intracranial Aneurysms.

Ziyuan Huang1, Cong Ling1

  • 1Department of Neurosurgery, The Third Affiliated Hospital, Sun Yat-Sen University, Guangzhou, China.

World Neurosurgery
|July 11, 2025
PubMed
Summary
This summary is machine-generated.

Intracranial aneurysms (IAs) are common vascular conditions. This review explores IA pathophysiology and emphasizes developing noninvasive treatments for better patient outcomes.

Keywords:
HemodynamicsInflammatory responseIntracranial aneurysmsPathophysiology

More Related Videos

Double Direct Injection of Blood into the Cisterna Magna as a Model of Subarachnoid Hemorrhage
10:34

Double Direct Injection of Blood into the Cisterna Magna as a Model of Subarachnoid Hemorrhage

Published on: August 30, 2020

10.7K
Endovascular Perforation Model for Subarachnoid Hemorrhage Combined with Magnetic Resonance Imaging MRI
06:30

Endovascular Perforation Model for Subarachnoid Hemorrhage Combined with Magnetic Resonance Imaging MRI

Published on: December 16, 2021

3.9K

Related Experiment Videos

Last Updated: Sep 16, 2025

Pre-Chiasmatic, Single Injection of Autologous Blood to Induce Experimental Subarachnoid Hemorrhage in a Rat Model
09:14

Pre-Chiasmatic, Single Injection of Autologous Blood to Induce Experimental Subarachnoid Hemorrhage in a Rat Model

Published on: June 18, 2021

2.5K
Double Direct Injection of Blood into the Cisterna Magna as a Model of Subarachnoid Hemorrhage
10:34

Double Direct Injection of Blood into the Cisterna Magna as a Model of Subarachnoid Hemorrhage

Published on: August 30, 2020

10.7K
Endovascular Perforation Model for Subarachnoid Hemorrhage Combined with Magnetic Resonance Imaging MRI
06:30

Endovascular Perforation Model for Subarachnoid Hemorrhage Combined with Magnetic Resonance Imaging MRI

Published on: December 16, 2021

3.9K

Area of Science:

  • Cerebrovascular disorders
  • Neuroscience
  • Pathophysiology

Background:

  • Intracranial aneurysms (IAs) are dilations of cerebral arteries with a 2-3% prevalence.
  • While often asymptomatic, IA rupture causes subarachnoid hemorrhage, leading to disability or death.
  • Increasing detection of unruptured IAs highlights the need for better understanding and management.

Purpose of the Study:

  • To comprehensively review the pathophysiological mechanisms of intracranial aneurysms.
  • To discuss current treatment modalities and their limitations.
  • To highlight the importance of developing novel, noninvasive therapeutic strategies.

Main Methods:

  • Literature review of pathophysiological mechanisms of IAs.
  • Analysis of genetic, environmental, and hemodynamic factors.
  • Examination of vascular wall abnormalities and inflammatory responses.

Main Results:

  • IA formation is multifactorial, involving vascular wall defects, altered hemodynamics, and inflammation.
  • Current surgical treatments (clipping, coiling) have significant complication rates.
  • Noninvasive pharmacological interventions are crucial for future treatment.

Conclusions:

  • Understanding IA pathophysiology is key to developing effective treatments.
  • Precision medicine approaches tailored to individual profiles are essential.
  • Future research should prioritize noninvasive strategies to improve patient outcomes and reduce mortality.