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Anxiety and depression in cardiac amyloidosis: a systematic review

Simon Ghinassi1, Lucia Ponti2, Martina Smorti1

  • 1Department of Surgical, Medical and Molecular Pathology and Critical Care Medicine, University of Pisa, Pisa, Italy.

BMJ Open
|July 11, 2025
PubMed

Insights

Psychological distress is common in cardiac amyloidosis (CA) patients. Addressing mental health needs can improve patient outcomes and treatment adherence for this rare, serious condition.

Area of Science:

  • Cardiology
  • Psychiatry
  • Systematic Review

Background:

  • Cardiac amyloidosis (CA) is a rare, underdiagnosed condition with high mortality.
  • Increasing attention has focused on the link between CA and psychological distress.
  • Existing evidence requires systematization to guide clinical practice.

Purpose of the Study:

  • To systematically review and synthesize evidence on the relationship between cardiac amyloidosis and psychological distress.
  • To identify the prevalence and impact of psychological distress in CA patients.
  • To provide a comprehensive overview of the current literature.

Main Methods:

  • A systematic review was conducted following PRISMA guidelines.
  • Searches were performed on PubMed, ScienceDirect, Scopus, and Web of Science without time restrictions.
  • Inclusion criteria specified original quantitative research in English, exploring the CA-psychological distress relationship using validated measures.

Main Results:

  • Fourteen articles were selected for review, with quality scores ranging from 12 to 18.
  • A significant prevalence of psychological distress was found in patients with cardiac amyloidosis.
  • Associations between disease severity and psychological distress were heterogeneous across studies.

Conclusions:

  • Psychological distress is a critical factor in managing cardiac amyloidosis.
  • Integrating psychological assessment and support can enhance patient outcomes.
  • Improved mental health support may reduce disease burden and improve treatment adherence in CA patients.
Abstract

Keywords:
Anxiety disordersCARDIOLOGYDepression & mood disordersPsychological StressSystematic Review

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