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Noninvasive Assessment of Cardiac Abnormalities in Experimental Autoimmune Myocarditis by Magnetic Resonance Microscopy Imaging in the Mouse
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The Pivotal Role of Cardiac Magnetic Resonance Imaging in Diagnosing Chronic Chagas Cardiomyopathy

Syed H Ali1, Umer N Khan1, Nihar Chandupatla1

  • 1Internal Medicine, Dell Medical School, The University of Texas at Austin, Austin, Texas, USA.

JACC. Case Reports
|July 11, 2025
PubMed

Insights

Chronic Chagas cardiomyopathy (CCM) can cause dangerous arrhythmias. Early diagnosis using cardiac MRI in nonendemic areas is key for timely treatment and preventing sudden cardiac death.

Area of Science:

  • Cardiology
  • Infectious Diseases
  • Medical Imaging

Background:

  • Chronic Chagas cardiomyopathy (CCM) presents with myocardial fibrosis, increasing ventricular arrhythmia risk.
  • CCM is often underdiagnosed in nonendemic regions, necessitating heightened clinical suspicion.

Observation:

  • Two Hispanic patients without prior Chagas disease history presented with life-threatening ventricular arrhythmias.
  • Cardiac magnetic resonance imaging (CMR) was crucial in identifying myocardial fibrosis and scarring consistent with CCM.

Findings:

  • Both patients received implantable cardioverter-defibrillators for secondary prevention of sudden cardiac death.
  • Guideline-directed medical therapy and device implantation led to significant clinical improvement.

Implications:

  • Cardiac MRI is vital for diagnosing CCM-related myocardial fibrosis and guiding treatment strategies.
  • Increased awareness and advanced imaging are essential for timely CCM diagnosis and management in nonendemic settings.

Keywords:
cardiac magnetic resonance imagingcardiomyopathyventricular fibrillationventricular tachycardia

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