Related Experiment Video

Updated: Sep 16, 2025

Primary Outcome Assessment in a Pig Model of Acute Myocardial Infarction
14:19

Primary Outcome Assessment in a Pig Model of Acute Myocardial Infarction

Published on: October 14, 2016

11.7K

Pseudoinfarction Q Waves From a Stiff Heart: Classic But Commonly Overlooked Presentation of Cardiac Amyloidosis

Andrew S Kao1, Vanessa Liu1, Marcus A Urey2

  • 1Department of Medicine, University of California-San Diego, San Diego, California, USA.

JACC. Case Reports
|July 11, 2025
PubMed

Insights

Cardiac amyloidosis (CA) is a heart condition caused by amyloid buildup. Early diagnosis of light chain CA is crucial, as delays can significantly impact patient outcomes despite classic symptoms.

Area of Science:

  • Cardiology
  • Cardiovascular Diseases
  • Amyloidosis

Background:

  • Cardiac amyloidosis (CA) is a severe infiltrative cardiomyopathy.
  • Amyloid fibril deposition in the myocardium leads to restrictive cardiomyopathy.
  • Light chain CA is a rapidly progressive form with poor prognosis if untreated.

Purpose of the Study:

  • To highlight diagnostic challenges in light chain cardiac amyloidosis.
  • To emphasize the importance of timely diagnosis in CA.
  • To present a case of delayed diagnosis despite classic findings.

Main Methods:

  • Case report presentation.
  • Review of clinical presentation.
  • Analysis of diagnostic delays.

Main Results:

  • The case involved a middle-aged woman with light chain CA.
  • Diagnosis was significantly delayed.
  • Classic presentation findings, including a pseudoinfarction electrocardiographic pattern, were present.

Conclusions:

  • Diagnostic delays in light chain CA can occur even with classic symptoms.
  • Timely recognition and diagnosis are critical for improving outcomes in CA patients.
  • Awareness of pseudoinfarction patterns in CA is important for early detection.

Keywords:
cardiac amyloidosispseudoinfarction Q waves

More Related Videos

Myocardial Infarction and Functional Outcome Assessment in Pigs12:03

Myocardial Infarction and Functional Outcome Assessment in Pigs

Published on: April 25, 2014

28.1K
A Cryoinjury Model to Study Myocardial Infarction in the Mouse06:29

A Cryoinjury Model to Study Myocardial Infarction in the Mouse

Published on: September 19, 2019

9.5K

Related Concept Videos

Acute Coronary Syndrome II: Pathophysiology and Clinical Manifestations01:19

Acute Coronary Syndrome II: Pathophysiology and Clinical Manifestations

The pathophysiology of Acute Coronary Syndrome [ACD] involves several key processes:The main underlying cause of ACD is atherosclerosis, a chronic inflammatory disease characterized by the buildup of lipid-laden plaques within the coronary arteries.As the atherosclerotic plaque grows in the coronary artery, it may become unstable due to the formation of a lipid-rich core and a thin fibrous cap. Inflammatory cells within the plaque, such as macrophages, secrete enzymes that degrade the...
47
Endocarditis II: Clinical Features of Infective Endocarditis01:25

Endocarditis II: Clinical Features of Infective Endocarditis

Endocarditis can present various clinical features depending on the causative organism and the patient's underlying health conditions. Initially, the clinical features of infective endocarditis develop gradually, presenting with nonspecific symptoms that can be easily mistaken for other illnesses.General SymptomsEarly symptoms of infective endocarditis are fever, chills, weakness, malaise, fatigue, and weight loss. These symptoms reflect the systemic nature of the infection and the body's...
28
Myocarditis I: Introduction01:21

Myocarditis I: Introduction

Myocarditis is inflammation of the myocardium, which is the muscular layer of the heart.EtiologyMyocarditis has a diverse etiology, including a wide range of infectious and non-infectious causes:Infectious CausesViral: Common viruses include Coxsackie A and B, adenovirus, parvovirus B19, enteroviruses, and influenza A.Bacterial: Examples include infections caused by Streptococcus, Staphylococcus, and Mycoplasma species.Rickettsial: Infections like Rocky Mountain spotted fever can result in...
34
Myocarditis II: Clinical Features and Diagnostic Tests01:27

Myocarditis II: Clinical Features and Diagnostic Tests

Myocarditis is an inflammation of the heart muscle. The symptoms vary widely, encompassing asymptomatic presentations to severe, acute manifestations.Clinical PresentationAsymptomatic cases: In some instances, myocarditis may be asymptomatic, with the infection resolving without intervention. These cases often go undetected unless discovered incidentally through diagnostic imaging or tests conducted for other reasons.General Early Symptoms: Early symptoms of myocarditis are non-specific and can...
25
Acute Coronary Syndrome III: Diagnostic Studies01:30

Acute Coronary Syndrome III: Diagnostic Studies

Diagnosing acute coronary syndrome or ACS begins with a thorough patient history. Notable symptoms include central, crushing chest pain radiating to the left arm, neck, jaw, or back, along with shortness of breath, sweating (diaphoresis), nausea, vomiting, dizziness, and palpitations.It is crucial to note any history of cardiac illnesses and assess risk factors, including age, gender, smoking, hypertension, diabetes, hyperlipidemia, and a sedentary lifestyle.During physical examination, vital...
25
Acute Coronary Syndrome I: Introduction01:30

Acute Coronary Syndrome I: Introduction

Acute Coronary Syndrome (ACS) encompasses a spectrum of heart conditions caused by sudden obstruction of coronary arteries, typically resulting from the rupture of an atherosclerotic plaque and subsequent thrombus (blood clot) formation. This obstruction can lead to partial or complete blockage of blood flow, causing varying degrees of myocardial ischemia or infarction.ACS includes the following clinical entities:Unstable Angina (UA)Non-ST-Elevation Myocardial Infarction (NSTEMI)ST-Elevation...
80