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Recurrent Cardiac Myxoma: Insights From a Fourth Recurrence

Manuela Cristina Ribeiro Dias Barroso1, Heleutério da Conceição Nicolau Madogolele1, Hernán Patrício García Mejía1

  • 1Instituto do Coração (InCor), Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo, São Paulo, Brazil.

JACC. Case Reports
|July 11, 2025
PubMed

Insights

Recurrent cardiac myxomas, rare in benign tumors, occurred in a patient with Carney complex (CNC). This case highlights the need for advanced imaging and genetic testing for managing this rare syndrome.

Area of Science:

  • Cardiology
  • Genetics
  • Oncology

Background:

  • Cardiac myxomas are the most common benign cardiac tumors.
  • Recurrences are rare, typically associated with Carney complex (CNC).

Observation:

  • A 49-year-old woman with CNC experienced recurrent cardiac myxomas requiring four surgeries over 14 years.
  • She developed an ischemic stroke, necessitating further interventions.

Findings:

  • Carney complex is a rare autosomal dominant syndrome.
  • Recurrent cardiac myxomas in CNC can affect multiple heart chambers.

Implications:

  • This case emphasizes the critical role of advanced imaging techniques like echocardiography and MRI.
  • Early diagnosis and genetic evaluation are crucial for effective management of CNC and its cardiac manifestations.
Abstract

Keywords:
Carney complexmyxoma recurrence managementrecurrent cardiac myxoma

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