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Investigating Aortic Valve Calcification via Isolation and Culture of T Lymphocytes using Feeder Cells from Irradiated Buffy Coat
Published on: February 4, 2021
Marantic Endocarditis of the Aortic Valve Associated With Lymphoma
Emanuelle C M Santos1, Guilherme Pacheco1, Daniel F Luciano1
1Medical Sciences Research Center, University Center for the Development of Alto Vale, Rio do Sul, Brazil.
Background:
Marantic endocarditis (ME) is a noninfectious valvular condition characterized by friable vegetations that result in platelet thrombi, often associated with advanced malignancies.
Case Summary:
A 56-year-old woman admitted with asthenia, weight loss, dyspnea, and fever. Transthoracic echocardiography revealed a vegetative lesion on the ventricular side of the bicuspid aortic valve and computed tomography showed mediastinal mass. Patient was referred for valve replacement surgery and biopsy. Biopsy revealed diffuse large B-cell lymphoma and verrucous endocarditis. Patient died after surgery.
Discussion:
ME is rare, generally associated with advanced malignancies or autoimmune diseases and can be a worsening prognosis cause. This is the first case reported of ME associated with diffuse large B-cell lymphoma, highlighting the importance of considering this differential diagnosis.
Take-Home Messages:
Despite being challenging, ME is an important differential diagnosis. The association between ME and hematological tumors needs to be better studied to understand its pathophysiology.
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