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Treatment With Inclisiran During Peritoneal Dialysis
Elena Sani1, Elisabetta Rinaldi1, Maria Giovanna Lupo2
1Division of Endocrinology, Diabetes and Metabolism, University of Verona, Verona, Italy.
JACC. Case Reports
|July 11, 2025
Summary
Inclisiran effectively lowers low-density lipoprotein cholesterol in patients on peritoneal dialysis. This small interfering RNA therapy shows promise for lipid management in end-stage renal disease patients.
Area of Science:
- Cardiovascular Medicine
- Pharmacology
- Nephrology
Background:
- Inclisiran is a small interfering RNA (siRNA) targeting PCSK9 (proprotein convertase subtilisin/kexin type 9) synthesis to reduce low-density lipoprotein cholesterol (LDL-C).
- Previous trials demonstrated inclisiran's efficacy and safety across varying degrees of renal impairment.
- Limited data exist regarding inclisiran's use in patients undergoing peritoneal dialysis (PD).
Observation:
- A case study involved a 47-year-old woman with end-stage renal disease on PD and a history of severe cardiovascular disease.
- The patient received an injection of inclisiran.
Findings:
- Significant reduction in LDL-C by 56.2% at 3 months post-inclisiran administration.
- Observed decreases in apolipoprotein B, lipoprotein(a), and PCSK9 levels.
- The treatment was well-tolerated with no reported adverse effects.
Implications:
- Inclisiran may be a viable therapeutic option for lipid management in patients on peritoneal dialysis.
- Results suggest comparable efficacy and tolerability to those seen in broader clinical trials.
- This case highlights a potential new treatment avenue for dyslipidemia in end-stage renal disease patients on PD.
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