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Related Experiment Video

Updated: Sep 16, 2025

Preparation of Parasagittal Slices for the Investigation of Dorsal-ventral Organization of the Rodent Medial Entorhinal Cortex

Preparation of Parasagittal Slices for the Investigation of Dorsal-ventral Organization of the Rodent Medial Entorhinal Cortex

Published on: March 28, 2012

Direct entorhinal control of CA1 temporal coding.

Matteo Guardamagna^1,2, Oscar Chadney¹, Federico Stella²

¹Kavli Institute for Systems Neuroscience and Centre for Neural Computation, Norwegian University of Science and Technology, Trondheim, Norway.

Nature Communications

|July 11, 2025

Summary

This summary is machine-generated.

Inhibiting direct entorhinal inputs to the hippocampus (CA1) impaired theta phase precession but unexpectedly strengthened theta sequences, suggesting complex circuit dynamics govern sequence organization and learning.

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Last Updated: Sep 16, 2025

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Optogenetic Entrainment of Hippocampal Theta Oscillations in Behaving Mice

Optogenetic Entrainment of Hippocampal Theta Oscillations in Behaving Mice

Published on: June 29, 2018

Area of Science:

Neuroscience
Computational Neuroscience
Systems Neuroscience

Background:

Theta sequences in the hippocampus (CA1) are crucial for planning and prediction.
These sequences are influenced by inputs from CA3 and the entorhinal cortex (layer III).

Purpose of the Study:

To investigate the specific role of direct entorhinal inputs in shaping hippocampal theta sequences.
To determine how inhibiting entorhinal input affects spatial coding and theta phase precession in CA1.

Main Methods:

Utilized optogenetic inhibition to selectively target entorhinal layer III inputs to CA1.
Maintained the integrity of the rest of the hippocampal trisynaptic circuit.
Assessed spatial coding properties and theta phase precession dynamics.

Main Results:

Hippocampal CA1 spatial coding remained largely unaffected by the inhibition.
The slope and range of theta phase precession were significantly impaired.
Theta sequences were unexpectedly strengthened, despite impaired precession.

Conclusions:

Hippocampal sequence organization is not solely dependent on phase precession.
Circuit-level dynamics within the trisynaptic circuit are critical for sequence organization.
Direct entorhinal inputs may function as a supervisory signal for learning and representational updates.