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Association between monocyte to high-density lipoprotein cholesterol ratio and thyroid function: a cross-sectional
Lingling Zeng1,2,3, Suyun Yang4,5
1College of Nursing, Shanxi Medical University, Taiyuan, Shanxi, China.
Scientific Reports
|July 11, 2025
Summary
The Monocyte to HDL-C ratio (MHR) is linked to thyroid function in adults. Higher MHR correlates with increased levels of free triiodothyronine (FT3), total triiodothyronine (TT3), and total thyroxine (TT4).
Area of Science:
- Endocrinology
- Clinical Chemistry
- Public Health
Background:
- Thyroid dysfunction affects numerous bodily functions.
- The Monocyte to high-density lipoprotein cholesterol ratio (MHR) is an emerging inflammatory marker.
- Understanding MHR's relationship with thyroid function is crucial for metabolic health.
Purpose of the Study:
- To investigate the association between MHR and thyroid function indicators in a large adult population.
- To explore potential correlations between MHR and thyroid hormones (FT3, TT3, TT4) and antibodies (TPOAb).
Main Methods:
- Cross-sectional analysis of 6,963 adults from the 2007-2012 NHANES.
- Weighted multivariate linear regression models to assess MHR and thyroid function.
- Subgroup analyses and smoothed curve fitting to identify influencing factors and non-linear relationships.
Main Results:
- lnMHR showed positive correlations with FT3, TT3, and TT4.
- A J-shaped association was observed between lnMHR and FT3/TT4.
- MHR's relationship with thyroid function was modulated by age, BMI, UIC, and hypertension.
Conclusions:
- MHR is significantly associated with thyroid function indicators in adults.
- The observed associations suggest MHR may play a role in thyroid health.
- Further research is warranted to elucidate the causal mechanisms and clinical implications.
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