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Nonspecific immunostimulation against viruses.

B B Mallick, S Kishore, S K Das

    Comparative Immunology, Microbiology and Infectious Diseases
    |January 1, 1985
    PubMed
    Summary
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    Mycobacterium phlei (NSI) non-specifically boosts immunity against viral infections in mice, chicks, and guinea pigs. This immunostimulation involves cell-mediated immune response and unique inhibitory substances, not classical antibodies.

    Area of Science:

    • Immunology
    • Virology
    • Microbiology

    Background:

    • Non-specific immune stimulation can offer broad protection against various pathogens.
    • Mycobacterium species are known for their immunomodulatory properties.

    Purpose of the Study:

    • To investigate the non-specific immunostimulatory effects of a Mycobacterium phlei (NSI) preparation.
    • To elucidate the mechanisms underlying this non-specific viral resistance in different animal models.

    Main Methods:

    • Administration of a trypsinized Mycobacterium phlei (NSI) preparation to mice, chicks, and guinea pigs.
    • Exposure to Rabies virus, Marek's disease virus, and Foot and Mouth disease virus.
    • Assessment of immune responses using lymphocyte transformation tests, lymphokine (LyIF) assays, and migration inhibition tests (LMIT).

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  • Characterization of inhibitory substances in serum and their neutralization capabilities.
  • Electrophoretic analysis of serum globulin fractions.

    • Main Results:

    • NSI induced non-specific resistance against RNA and DNA viruses in diverse hosts.
    • Strong cell-mediated immune response (CMIR) was observed against viral antigens.
    • Induction of "Infectivity inhibiting substance(s)" (IIS), distinct from classical antibodies, which neutralized multiple viruses.
    • Electrophoresis showed an increase in the beta-globulin fraction of serum.

    Conclusions:

    • Mycobacterium phlei (NSI) acts as a potent non-specific immunostimulant.
    • The mechanism involves robust CMIR and the production of novel viral inhibitory substances.
    • NSI demonstrates potential as a broad-spectrum antiviral agent.