Causal relationships between inflammatory mediators, sleep traits, and cardiac magnetic resonance imaging-derived...

This study investigated the causal relationships between cytokines, chemokines, neutrophil-related factors, sleep traits, and CMR-derived cardiovascular phenotypes using two-sample Mendelian randomization (MR) analysis. The primary method employed was inverse variance weighted (IVW) analysis, supplemented with MR-Egger and weighted median analyses. We identified 24 significant associations, excluding the SNP rs2001329 related to sleep duration. Notably, CXCL9 showed a strong association with right ventricular peak atrial filling rate (OR = 587.45), while IL-5 was associated with right ventricular stroke volume (OR = 2.45). IL-7 and IL-18 significantly impacted four CMR-derived phenotypes each. Left ventricular ejection fraction was frequently affected by IL-1β, IL-18, CCL2, CXCL9, and NETs. Sensitivity analyses indicated minimal pleiotropy or heterogeneity except for sleep duration. This research highlights crucial cytokines and chemokines that modulate cardiac function through their relationships with cardiovascular phenotypes.