Serum alkaline phosphatase elevation as a preoperative sarcopenic biomarker in digestive cancer: a retrospective cohort study
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View abstract on PubMed
Summary
This summary is machine-generated.Elevated serum alkaline phosphatase (ALP) may indicate sarcopenia risk in preoperative digestive cancer patients. This chronic inflammation marker could help identify patients needing intervention before surgery.
Area Of Science
- Oncology
- Gastroenterology
- Geriatrics
- Biochemistry
Background
- Sarcopenia is linked to poor prognosis and postsurgical complications in preoperative patients.
- The mechanism of sarcopenia in cancer patients is not fully understood.
- Chronic inflammation is implicated in sarcopenia development.
Purpose Of The Study
- To investigate if elevated serum alkaline phosphatase (ALP) can serve as a preoperative sarcopenia marker in patients with digestive cancer.
- To explore the association between chronic inflammation, indicated by ALP, and sarcopenia in this patient group.
Main Methods
- Retrospective analysis of electronic medical records from 274 patients with digestive cancer.
- Patients were categorized into sarcopenia (SC) and nonsarcopenia (NSC) groups based on perioperative screening.
- Statistical analysis was performed, accounting for confounders like age, liver function, and bone fractures.
Main Results
- Serum ALP levels were significantly higher in the sarcopenia group (168.4 U/L) compared to the nonsarcopenia group (100.4 U/L).
- Elevated ALP showed a significant correlation with sarcopenia risk (p=0.0018, OR=1.0055).
- Significant differences were observed in albumin, hemoglobin, neutrophil-to-lymphocyte ratio, and malnutrition parameters between groups.
Conclusions
- Serum ALP elevation, potentially due to chronic inflammation, is correlated with sarcopenia in preoperative digestive cancer patients.
- ALP may serve as a useful biomarker for identifying sarcopenia risk in this population.
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