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Updated: Sep 16, 2025

Using a Murine Model of Psychosocial Stress in Pregnancy as a Translationally Relevant Paradigm for Psychiatric Disorders in Mothers and Infants
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Epiphenomena in psychosis: how perinatal stressful events shape long-term outcomes

Clemente Garcia-Rizo1,2,3,4, Byron K Y Bitanihirwe5

  • 1Barcelona Clinic Schizophrenia Unit, Neuroscience Institute, Hospital Clinic, Barcelona, Spain. cgarcia3@clinic.cat.

Molecular Psychiatry
|July 11, 2025
PubMed

Insights

Perinatal stress increases the risk of psychosis and related issues like metabolic problems and brain changes in offspring. This research explores how these early life events contribute to psychosis development and its long-term health impacts.

Area of Science:

  • Neuroscience
  • Psychiatry
  • Developmental Psychology

Background:

  • Perinatal stress is linked to increased risk of mental health issues, including psychosis.
  • Offspring exposed to maternal stress during pregnancy may develop neurodevelopmental disorders.
  • Epiphenomena such as metabolic disturbances, brain abnormalities, and cognitive impairment are associated with perinatal stress and psychosis.

Purpose of the Study:

  • To discuss clinical features of psychosis from a translational perspective, linking them to perinatal stress.
  • To elaborate a hypothetical model explaining metabolic manifestations in adulthood due to perinatal events.
  • To provide a framework for understanding the long-term 'scars' of perinatal stress in psychosis for public health.

Main Methods:

  • Translational research approach linking perinatal stress to psychosis.
  • Development of a hypothetical model for metabolic manifestations.
  • Review and synthesis of clinical features, brain abnormalities, and cognitive impairment.

Main Results:

  • Perinatal stress is associated with a higher risk of psychosis and diverse epiphenomena.
  • A model is proposed to explain adult metabolic issues stemming from perinatal events.
  • The study framework connects perinatal stress 'scars' to psychosis and public health concerns.

Conclusions:

  • Perinatal stress is a significant factor in the development of psychosis and associated health problems.
  • Understanding the link between perinatal stress and psychosis is crucial for public health strategies.
  • Further research into the proposed metabolic model can elucidate psychosis morbidity and mortality.

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